Key Laboratory of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, China.
Macromol Biosci. 2011 Jun 14;11(6):797-805. doi: 10.1002/mabi.201000474. Epub 2011 Mar 7.
A facile approach to a highly bio-active interface material is reported. XPS reveals that polar entities exist at the interface between PPAam and PPAac nanolayers. They induce strong dipolar orientation polarizability and cause the redistribution of charges, which results in a remarkable increase of polar surface energy and hydrophilicity of the multistack bipolar films. In particular bipolar films with amine groups on their outermost surface show strongly enhanced cellular mobility. The attachment, adhesion, proliferation, migration, and coverage of ECs are significantly enhanced on such films. They are therefore promising as vascular implant materials, and could have applications as coating materials for tissue engineering.
本文报道了一种制备高生物活性界面材料的简易方法。XPS 表明，在 PPAam 和 PPAac 纳米层之间的界面处存在极性实体。它们诱导强偶极定向极化率，并导致电荷重新分布，从而显著增加多层双极膜的极性表面能和亲水性。特别是最外层带有胺基的双极膜显示出强烈增强的细胞迁移率。ECs 的附着、黏附、增殖、迁移和覆盖在这些膜上显著增强。因此，它们有望作为血管植入材料，并可作为组织工程的涂层材料。
