Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691, Stockholm, Sweden.
Org Lett. 2011 Apr 1;13(7):1888-91. doi: 10.1021/ol200445b. Epub 2011 Mar 8.
Palladium-catalyzed allylic C-H silylation was performed with use of hexamethyldisilane as the silyl source. These C-H functionalization reactions occur only in the presence of hypervalent iodine reagents or other strong oxidants and proceed with excellent regioselectivity, providing the linear allylic isomer of the allylsilane products. In demonstrating the first oxidative allylic C-H silylation of alkenes, this study marks an important advance for the catalytic C-H functionalization method.
钯催化烯丙基 C-H 硅烷化反应使用六甲基二硅烷作为硅源进行。这些 C-H 官能团化反应仅在高价碘试剂或其他强氧化剂存在下发生，具有极好的区域选择性，提供烯丙基硅烷产物的线性烯丙基异构体。在展示烯烃的首次氧化烯丙基 C-H 硅烷化反应中，这项研究标志着催化 C-H 官能团化方法的重要进展。
