高价碘试剂与钯的反应：机理及在有机合成中的应用

Reactions of hypervalent iodine reagents with palladium: mechanisms and applications in organic synthesis.

作者信息

Deprez Nicholas R, Sanford Melanie S

机构信息

Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.

出版信息

Inorg Chem. 2007 Mar 19;46(6):1924-35. doi: 10.1021/ic0620337.

DOI:10.1021/ic0620337

PMID:17348723

Abstract

The unique reactivity of hypervalent iodine reagents with Pd0 and PdII complexes has been exploited for a variety of synthetically useful organic transformations. For example, IIII reagents have been used in place of aryl halides for diverse Pd-catalyzed C-C and C-heteroatom bond-forming cross-coupling reactions. In addition, these reagents have found application in Pd-catalyzed oxidation reactions, including the oxidative functionalization of C-H bonds and the 1,2-aminooxygenation of olefinic substrates. This review discusses both the synthetic utility and the interesting mechanistic features of these transformations.

摘要

高价碘试剂与Pd0和PdII配合物的独特反应活性已被用于各种具有合成价值的有机转化反应。例如，IIII试剂已被用于替代芳基卤化物，用于各种钯催化的C-C和C-杂原子键形成的交叉偶联反应。此外，这些试剂已在钯催化的氧化反应中得到应用，包括C-H键的氧化官能团化和烯烃底物的1,2-氨基氧化反应。本文综述了这些转化反应的合成效用和有趣的机理特征。