Chemistry Division, School of Advanced Sciences (SAS), Vellore Institute of Technoloy-Chennai, Chennai 600127, Tamil Nadu, India.
College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-0058, Shiga, Japan.
Molecules. 2022 Jun 17;27(12):3900. doi: 10.3390/molecules27123900.
The chemistry of polyvalent iodine compounds has piqued the interest of researchers due to their role as important and flexible reagents in synthetic organic chemistry, resulting in a broad variety of useful organic molecules. These chemicals have potential uses in various functionalization procedures due to their non-toxic and environmentally friendly properties. As they are also strong electrophiles and potent oxidizing agents, the use of hypervalent iodine reagents in palladium-catalyzed transformations has received a lot of attention in recent years. Extensive research has been conducted on the subject of C-H bond functionalization by Pd catalysis with hypervalent iodine reagents as oxidants. Furthermore, the iodine(III) reagent is now often used as an arylating agent in Pd-catalyzed C-H arylation or Heck-type cross-coupling processes. In this article, the recent advances in palladium-catalyzed oxidative cross-coupling reactions employing hypervalent iodine reagents are reviewed in detail.
多价碘化合物的化学性质引起了研究人员的兴趣，因为它们在合成有机化学中作为重要且灵活的试剂，可产生多种有用的有机分子。由于这些化学品具有无毒和环保的特性，因此它们在各种功能化过程中有潜在的用途。由于它们也是强亲电试剂和强氧化剂，近年来，高价碘试剂在钯催化转化中的应用受到了广泛关注。人们对 Pd 催化的 C-H 键官能化反应中使用高价碘试剂作为氧化剂进行了广泛的研究。此外，碘（III）试剂现在通常用作 Pd 催化的 C-H 芳基化或 Heck 型交叉偶联过程中的芳基化试剂。本文详细综述了钯催化的使用高价碘试剂的氧化交叉偶联反应的最新进展。
