Joint Center of Biomedical Imaging of Department of Chemistry & Institute of Biomedical Science & Cancer Hospital, Advanced Materials Laboratory, Fudan University, 200433, People's Republic of China.
ACS Nano. 2011 Apr 26;5(4):3146-57. doi: 10.1021/nn200298y. Epub 2011 Mar 16.
A novel method of rare-earth cation-assisted ligand assembly has been developed to provide upconversion nanophosphors with T(1)-enhanced magnetic resonance (MR), radioactivity, and targeted recognition properties, making these nanoparticles potential candidates for multimodal bioimaging. The process of modifying the surface of the nanophosphors has been confirmed by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, energy-dispersive X-ray analysis, and so on. The versatility of this surface modification approach for incorporating functional molecules and fabricating fluorine-18-labeled magnetic-upconversion nanophosphors as multimodal bioprobes has been demonstrated by targeted cell imaging, in vivo upconversion luminescence, MR imaging, and positron emission tomography imaging of whole-body small animals.
一种新型的稀土阳离子辅助配体组装方法已被开发出来，用于提供上转换纳米荧光粉，以增强 T(1)磁共振（MR）、放射性和靶向识别特性，使这些纳米粒子成为多模态生物成像的潜在候选者。纳米荧光粉表面修饰的过程已通过透射电子显微镜、X 射线粉末衍射、X 射线光电子能谱、质子核磁共振、傅里叶变换红外光谱、能谱分析等手段得到了证实。通过靶向细胞成像、体内上转换发光、MR 成像和小动物全身正电子发射断层扫描成像，证明了这种表面修饰方法在多功能生物探针中结合功能分子和制备氟-18 标记的磁上转换纳米荧光粉的多功能性。
