School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, UK.
Scand J Med Sci Sports. 2012 Jun;22(3):410-7. doi: 10.1111/j.1600-0838.2010.01272.x. Epub 2011 Mar 8.
The purpose of this study was to examine factors influencing susceptibility to upper respiratory tract infections (URTI) in 18-35-year-old men and women engaged in endurance-based physical activity during the winter months. Eighty individuals (46 males, 34 females) provided resting blood and saliva samples for determination of markers of systemic immunity. Weekly training and illness logs were kept for the following 4 months. Thirty subjects did not experience an URTI episode and 24 subjects experienced 3 or more weeks of URTI symptoms. These illness-prone subjects had higher training loads and had ∼2.5-fold higher interleukin (IL)-4 and IL-10 production by antigen-stimulated whole blood culture than the illness-free subjects. Illness-prone subjects also had significantly lower saliva S-IgA secretion rate and higher plasma IgM (but not IgA or IgG) concentration than the illness-free subjects. There were no differences in circulating numbers of leukocyte subtypes or lymphocyte subsets between the illness-prone and illness-free subjects. The production of IL-10 was positively correlated and the S-IgA secretion rate was negatively correlated with the number of weeks with infection symptoms. It is concluded that high IL-10 production in response to antigen challenge and low S-IgA secretion are risk factors for development of URTI in physically active individuals.
本研究旨在探讨 18-35 岁从事耐力性体育活动的男性和女性在上呼吸道感染（URTI）易感性方面的影响因素。80 名个体（46 名男性，34 名女性）提供了静息血液和唾液样本，以确定全身免疫标志物。在接下来的 4 个月中，每周记录训练和患病情况。30 名受试者没有经历 URTI 发作，24 名受试者经历了 3 周或更长时间的 URTI 症状。这些易患病的受试者的训练负荷更高，并且与无病受试者相比，抗原刺激全血培养中产生的白细胞介素（IL）-4 和 IL-10 增加了约 2.5 倍。易患病的受试者的唾液 S-IgA 分泌率也明显低于无病受试者，而血浆 IgM（但不是 IgA 或 IgG）浓度则高于无病受试者。易患病的受试者和无病受试者之间循环白细胞亚型或淋巴细胞亚群的数量没有差异。IL-10 的产生呈正相关，而 S-IgA 的分泌率与感染症状持续的周数呈负相关。结论是，抗原刺激后高水平的 IL-10 产生和低水平的 S-IgA 分泌是体育活动人群发生 URTI 的危险因素。
