Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Neurogastroenterol Motil. 2011 Jun;23(6):556-e207. doi: 10.1111/j.1365-2982.2011.01683.x. Epub 2011 Mar 8.
Sacral nerve stimulation (SNS) is a well-established treatment for fecal incontinence of various etiologies. However, the mechanism of action remains unclear. The aim of the present study was to determine whether SNS affects gastric emptying, small intestinal transit or colonic transit times.
Seven patients with a permanently implanted sacral nerve stimulator participated in a double-blind randomized cross-over study. The patients were allocated to stimulation ON or OFF for two 7-day periods separated by at least 1week. On days 4-7 of each 7-day period, the patients were examined by gamma camera imaging to measure gastric emptying, small intestinal transit and colonic transit parameters of a radiolabeled, 1600 kJ mixed solid and liquid meal ingested on day 4.
Sacral nerve stimulation did not change gastric retention at 15 min, gastric mean emptying time, gastric half emptying time, small intestinal mean transit time or colonic geometric center after 24, 48 and 72 h.
CONCLUSIONS & INFERENCES: Sacral nerve stimulation does not induce major changes in the propulsive capacity of the gastrointestinal tract in patients successfully treated for fecal incontinence with permanent sacral nerve stimulator.
骶神经刺激（SNS）是一种成熟的治疗各种病因性大便失禁的方法。然而，其作用机制尚不清楚。本研究旨在确定 SNS 是否会影响胃排空、小肠传输或结肠传输时间。
7 名植入永久性骶神经刺激器的患者参与了一项双盲随机交叉研究。患者被分配为刺激开启或关闭状态，两种状态各持续 7 天，其间至少间隔 1 周。在每个 7 天周期的第 4-7 天，通过伽马相机成像检查测量放射性标记的 1600kJ 混合固体和液体餐在第 4 天摄入后的胃排空、小肠传输和结肠传输参数。
骶神经刺激不会改变 15 分钟时的胃潴留、胃平均排空时间、胃半排空时间、小肠平均传输时间或 24、48 和 72 小时后的结肠几何中心。
在成功接受永久性骶神经刺激治疗大便失禁的患者中，骶神经刺激不会引起胃肠道推进能力的重大变化。
