University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium.
BMC Gastroenterol. 2011 Mar 8;11:17. doi: 10.1186/1471-230X-11-17.
Antipsychotic are the cornerstone in the treatment of schizophrenia. They also have a number of side-effects. Constipation is thought to be common, and a potential serious side-effect, which has received little attention in recent literature.
We performed a retrospective study in consecutively admitted patients, between 2007 and 2009 and treated with antipsychotic medication, linking different electronic patient data to evaluate the prevalence and severity of constipation in patients with schizophrenia under routine treatment conditions.
Over a period of 22 months 36.3% of patients (99) received at least once a pharmacological treatment for constipation. On average medication for constipation was prescribed for 273 days. Severe cases (N = 50), non-responsive to initial treatment, got a plain x-ray of the abdomen. In 68.4% fecal impaction was found.
A high prevalence of constipation, often severe and needing medical interventions, was confirmed during the study period. Early detection, monitoring over treatment and early intervention of constipation could prevent serious consequences such as ileus.
抗精神病药是治疗精神分裂症的基石。它们也有许多副作用。便秘被认为是常见的，也是一种潜在的严重副作用，但在最近的文献中却很少受到关注。
我们在 2007 年至 2009 年间连续收治的接受抗精神病药物治疗的患者中进行了一项回顾性研究，将不同的电子患者数据联系起来，以评估常规治疗条件下精神分裂症患者便秘的患病率和严重程度。
在 22 个月的时间里，36.3%的患者（99 人）至少接受过一次治疗便秘的药物治疗。平均而言，用于治疗便秘的药物开了 273 天。50 例严重病例（N=50）对初始治疗无反应，进行了腹部平片检查。68.4%的病例发现粪便嵌塞。
在研究期间，确认了便秘的高患病率，往往严重且需要医疗干预。早期发现、治疗监测和早期干预便秘可以预防肠梗阻等严重后果。
