Department of Nursing, Universidad Granada, Spain.
Biol Res Nurs. 2012 Jan;14(1):98-107. doi: 10.1177/1099800411398933. Epub 2011 Mar 8.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs worldwide and serve as treatment of some degenerative inflammatory joint diseases. The aim of the present study was to investigate the influence of different concentrations of three NSAIDs on cell proliferation, differentiation, antigenic profile, and cell cycle in the human MG-63 osteosarcoma cell line, incubated for 24 hr. All NSAIDs had an inhibiting effect on osteoblastic proliferation. Treatments for 24 hr had small but significant effects on the antigenic profile. No treatment altered osteocalcin synthesis. Indomethacin and nimesulide treatments arrested the cell cycle at G(0)/G(1). These results suggest that indomethacin, nimesulide, and diclofenac appear to have no effects on osteocalcin synthesis and a slight effect on the antigenic profile. They may delay bone regeneration due to their inhibiting effect on osteoblast growth. Therefore, these drugs should only be used in situations that do not require rapid bone healing.
非甾体抗炎药（NSAIDs）是全球应用最广泛的药物之一，可用于治疗一些退行性炎症性关节疾病。本研究旨在研究三种 NSAIDs 的不同浓度对人 MG-63 骨肉瘤细胞系增殖、分化、抗原表型和细胞周期的影响，孵育 24 小时。所有 NSAIDs 对成骨细胞增殖均有抑制作用。24 小时处理对抗原表型有微小但显著的影响。没有处理改变骨钙素的合成。吲哚美辛和尼美舒利处理将细胞周期阻滞在 G0/G1 期。这些结果表明，吲哚美辛、尼美舒利和双氯芬酸似乎对骨钙素合成没有影响，对抗原表型有轻微影响。由于其对成骨细胞生长的抑制作用，它们可能会延迟骨再生。因此，这些药物仅应在不需要快速骨愈合的情况下使用。
