Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
Instituto Investigación Biosanitaria, ibs.Granada, Granada, Spain.
PLoS One. 2018 Apr 26;13(4):e0196530. doi: 10.1371/journal.pone.0196530. eCollection 2018.
The reported incidence of osteoporosis is lower in countries in which the Mediterranean diet predominates, and this apparent relationship may be mediated by the phenolic compounds present in olive oil. The objective of this study was to determine the effect of phenolic extracts from different varieties of extra-virgin olive oil (Picual, Arbequina, Picudo, and Hojiblanca) on the differentiation, antigenic expression, and phagocytic capacity of osteoblast-like MG-63 cells. At 24 h of treatment a significant increase in phosphatase alkaline activity and significant reductions in CD54, CD80, and HLA-DR expression and in phagocytic activity were observed in comparison to untreated controls. The in vitro study performed has demonstrated that phenolic compounds from different extra virgin olive oil varieties can modulate different parameters related to osteoblast differentiation and function.
报告的骨质疏松症发病率在以地中海饮食为主的国家较低，这种明显的关系可能是由橄榄油中存在的酚类化合物介导的。本研究的目的是确定不同品种特级初榨橄榄油（皮夸尔、阿贝基纳、皮库多和霍奇布兰卡）的酚类提取物对成骨样 MG-63 细胞分化、抗原表达和吞噬能力的影响。在治疗 24 小时后，与未处理的对照组相比，碱性磷酸酶活性显著增加，CD54、CD80 和 HLA-DR 表达以及吞噬活性显著降低。体外研究表明，不同特级初榨橄榄油品种的酚类化合物可以调节与成骨细胞分化和功能相关的不同参数。
