Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, NY 10029, USA.
Sci Signal. 2011 Mar 8;4(163):pe12. doi: 10.1126/scisignal.2001874.
Signal transduction through Ras translates extracellular signals into biological responses, including cell proliferation, cell survival, growth, and differentiation. For these reasons, dysregulating Ras can have dramatic effects at the cellular and organismal levels. Germline mutations that increase Ras signaling disrupt development, whereas mutational activation of Ras in somatic cells can cause cancer. Thus, identifying additional mechanisms that positively or negatively regulate Ras could have profound implications for treating human diseases. New evidence identifies K-Ras monoubiquitination as a previously unknown means to potentiate Ras signaling.
通过 Ras 进行信号转导将细胞外信号转化为生物反应，包括细胞增殖、细胞存活、生长和分化。由于这些原因，Ras 的失调会在细胞和机体水平上产生巨大影响。增加 Ras 信号的种系突变会破坏发育，而 Ras 在体细胞中的突变激活会导致癌症。因此，鉴定出正调控或负调控 Ras 的其他机制可能对治疗人类疾病具有深远意义。新的证据表明，K-Ras 单泛素化是一种以前未知的增强 Ras 信号的手段。
