脂溢性角化病的棘层松解变异型。

Acantholytic variant of seborrheic keratosis.

作者信息

Chen M, Shinmori H, Takemiya M, Miki Y

机构信息

Department of Dermatology, University of Ehime School of Medicine, Japan.

出版信息

J Cutan Pathol. 1990 Feb;17(1):27-31. doi: 10.1111/j.1600-0560.1990.tb01674.x.

DOI:10.1111/j.1600-0560.1990.tb01674.x

PMID:2138642

Abstract

From among 524 histologic specimens of seborrheic keratosis (SK), 29 showed acantholysis, not related to pemphigus, Darier's disease, actinic keratosis or acantholytic squamous cell carcinoma. Acantholysis was found in 24 (23.3%) of the irritated type of SK, almost exclusively in the squamous cell nests showing dyskeratosis and spongiosis between and around squamous eddies or horn cysts. Clinically, 65.5% of the lesions were located on the face and scalp, 20.7% on the trunk and 13.8% on the limbs. It was speculated that dyskeratotic, degenerative changes of the keratinocytes together with spongiosis were responsible for the acantholysis.

摘要

在524份脂溢性角化病（SK）组织学标本中，有29份显示棘层松解，与天疱疮、 Darier病、光化性角化病或棘层松解性鳞状细胞癌无关。棘层松解见于24例（23.3%）刺激性SK，几乎仅见于鳞状细胞巢，这些巢在鳞状涡或角囊肿之间及周围显示角化不良和海绵形成。临床上，65.5%的皮损位于面部和头皮，20.7%位于躯干，13.8%位于四肢。推测角质形成细胞的角化不良、退行性改变以及海绵形成是棘层松解的原因。