Ciupinska M, Kalbarczyk K, Jablonska S
Warsaw Municipal Dermatological Hospital, Poland.
J Eur Acad Dermatol Venereol. 1998 Jul;11(1):55-8.
We present two cases of elderly women with clinically atypical transient disseminated papular eruption, showing suprabasal epidermal clefts with dyskeratosis and acantholysis. The clinical picture did not correspond to either Darier's disease, Hailey's disease or Grover's acantholysis. In spite of clinical similarity the cases differed in course and outcome. Overlapping dyskeratosis and acantholysis varied in different specimens. The case with transient acantholytic lesions of short duration showed much more pronounced dyskeratosis than the other in which several relapses occurred in a 4-year period. Such cases defying classification belong to the heterogeneous group of papular acantholytic dyskeratosis.
我们报告两例老年女性患者，其临床表现为非典型性短暂性播散性丘疹性皮疹，表现为基底层上方表皮裂隙伴角化不良和棘层松解。临床表现既不符合 Darier 病、Hailey 病，也不符合 Grover 棘层松解症。尽管临床表现相似，但这两例患者在病程和结局方面存在差异。不同标本中重叠的角化不良和棘层松解情况各不相同。病程短暂的短暂性棘层松解性皮损病例，其角化不良比另一例在 4 年期间多次复发的病例更为明显。此类难以分类的病例属于丘疹性棘层松解性角化不良这一异质性疾病组。
