Department of Ophthalmology, Albany Medical College, Albany, New York, USA.
Ophthalmic Plast Reconstr Surg. 2011 Jul-Aug;27(4):251-4. doi: 10.1097/IOP.0b013e31820768f7.
To identify the cytokines that are expressed in elevated concentrations in idiopathic orbital inflammation (IOI).
Experimental study.
Biopsy specimens from 8 patients with biopsy-proven IOI and negative serologic and radiographic examinations, versus orbital biopsy samples taken from 8 control patients without clinical evidence or subjective complaint of orbital inflammation.
Quantitative cytokine assays were performed to assess the levels of 9 different molecules for IOI and control patients. Statistical analyses were performed to compare the cytokine concentrations between the 2 groups.
Cytokine concentrations.
Six cytokines were statistically significantly elevated in IOI (interleukin-2, -8, -10, -12, gamma interferon, and tumor necrosis factor alpha) (p < 0.05). Gamma interferon and interleukin-12 were expressed at concentrations greater than 10 times higher in patients with IOI.
IOI involves discrete elevations of specific cytokines, and individual molecules are clearly implicated in the pathogenesis of this disease. Specifically, gamma interferon and interleukin-12 concentrations are markedly elevated in IOI. These cytokines represent novel therapeutic targets in the management of this inflammatory process. Agents that affect these molecules could be used as potential therapies to control this disease in a more effective fashion with fewer side effects.
鉴定特发性眼眶炎症（IOI）中高浓度表达的细胞因子。
实验研究。
8 例经活检证实的 IOI 患者和阴性血清学及影像学检查的活检标本，与 8 例无临床证据或眶内炎症主观主诉的对照患者的眼眶活检标本。
定量细胞因子检测评估 IOI 和对照患者 9 种不同分子的水平。统计学分析比较两组细胞因子浓度。
细胞因子浓度。
6 种细胞因子在 IOI 中统计学显著升高（白细胞介素-2、-8、-10、-12、γ干扰素和肿瘤坏死因子-α）（p<0.05）。IOI 患者γ干扰素和白细胞介素-12 的表达浓度高于对照组 10 倍以上。
IOI 涉及特定细胞因子的离散升高，个别分子显然与这种疾病的发病机制有关。具体而言，γ干扰素和白细胞介素-12 的浓度在 IOI 中明显升高。这些细胞因子在这种炎症过程的治疗中代表了新的治疗靶点。影响这些分子的药物可作为潜在的治疗方法，以更有效的方式控制这种疾病，副作用更少。
