Noma Hidetaka, Funatsu Hideharu, Mimura Tatsuya, Eguchi Shuichiro, Shimada Katsunori
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Yachiyo, Chiba, Japan;
Clin Ophthalmol. 2011;5:223-9. doi: 10.2147/OPTH.S16552. Epub 2011 Feb 15.
This study investigated whether vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and pigment epithelium-derived factor (PEDF) influence the visual prognosis of patients with macular edema and branch retinal vein occlusion (BRVO). In 47 consecutive patients (47 eyes) undergoing vitrectomy, retinal thickness was examined by optical coherence tomography. Best-corrected visual acuity and the vitreous fluid levels of VEGF, sICAM-1, and PEDF were also determined. Patients were followed for at least 6 months after surgery. Vitreous fluid levels of VEGF and sICAM-1 were significantly lower in the patients with more marked improvement of visual acuity after vitrectomy, while PEDF was significantly higher. VEGF and sICAM-1 levels were significantly higher in patients with greater postoperative improvement of macular edema, while PEDF was significantly lower. In BRVO patients, vitreous fluid levels of VEGF, sICAM-1, and PEDF may influence both the response of macular edema to vitrectomy and the visual prognosis.
本研究调查了血管内皮生长因子（VEGF）、可溶性细胞间黏附分子-1（sICAM-1）和色素上皮衍生因子（PEDF）是否影响黄斑水肿和视网膜分支静脉阻塞（BRVO）患者的视力预后。在47例连续接受玻璃体切除术的患者（47只眼）中，通过光学相干断层扫描检查视网膜厚度。还测定了最佳矫正视力以及玻璃体中VEGF、sICAM-1和PEDF的水平。术后对患者进行至少6个月的随访。玻璃体切除术后视力改善更明显的患者，其玻璃体中VEGF和sICAM-1水平显著降低，而PEDF水平显著升高。黄斑水肿术后改善更明显的患者，其VEGF和sICAM-1水平显著升高，而PEDF水平显著降低。在BRVO患者中，玻璃体中VEGF、sICAM-1和PEDF水平可能影响黄斑水肿对玻璃体切除术的反应以及视力预后。
