• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

眼内可溶性细胞间黏附分子-1与糖尿病性黄斑水肿的视网膜下液高度相关。

Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema.

作者信息

Zhu Dan, Zhu He, Wang Chunyan, Yang Dayong

机构信息

Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical College, Hohhot, Inner Mongolia, China.

出版信息

Indian J Ophthalmol. 2014 Mar;62(3):295-8. doi: 10.4103/0301-4738.111184.

DOI:10.4103/0301-4738.111184
PMID:23619489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4061666/
Abstract

OBJECTIVE

To investigate the correlations between aqueous concentrations of vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular edema (DME).

MATERIALS AND METHODS

VEGF, MCP-1 and sICAM-1 concentrations in aqueous humor samples of 22 patients with DME and 23 patients with cataract of a control group were measured with solid-phase chemiluminescence immunoassay.

RESULTS

Aqueous VEGF (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006), MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001) all vary significantly between DME group and control group. Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034). The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285).

CONCLUSIONS

Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.

摘要

目的

探讨房水中血管内皮生长因子（VEGF）、单核细胞趋化蛋白-1（MCP-1）、可溶性细胞间黏附分子-1（sICAM-1）浓度与糖尿病性黄斑水肿（DME）之间的相关性。

材料与方法

采用固相化学发光免疫分析法检测22例DME患者和23例对照组白内障患者房水样本中VEGF、MCP-1和sICAM-1的浓度。

结果

DME组与对照组房水中VEGF（89.2±58.5 pg/ml对48.5±27.8 pg/ml，P = 0.006）、MCP-1（684.2±423.4 pg/ml对432.4±230.4 pg/ml，P = 0.019）和sICAM-1（3213.8±2581.6 pg/ml对260.2±212.2 pg/ml，P < 0.001）均有显著差异。光学相干断层扫描（OCT）测量的黄斑下液最大高度与房水sICAM-1显著相关（r = -0.45，P = 0.034）。OCT测量的黄斑厚度最大高度与VEGF（P = 0.300）、MCP-1（P = 0.320）或sICAM-1（P = 0.285）均无显著相关性。

结论

我们的结果表明，sICAM-1可能在DME患者视网膜下液的形成中起主要作用，提示MCP-1和sICAM-1可能是除VEGF之外的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/3f2488b0fb59/IJO-62-295-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/f0c11166bc89/IJO-62-295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/b1aa83e85fc3/IJO-62-295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/285afa9929f6/IJO-62-295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/e875a509e190/IJO-62-295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/3f2488b0fb59/IJO-62-295-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/f0c11166bc89/IJO-62-295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/b1aa83e85fc3/IJO-62-295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/285afa9929f6/IJO-62-295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/e875a509e190/IJO-62-295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/4061666/3f2488b0fb59/IJO-62-295-g006.jpg

相似文献

1
Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema.眼内可溶性细胞间黏附分子-1与糖尿病性黄斑水肿的视网膜下液高度相关。
Indian J Ophthalmol. 2014 Mar;62(3):295-8. doi: 10.4103/0301-4738.111184.
2
Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration.渗出性年龄相关性黄斑变性中的单核细胞趋化蛋白1、细胞间黏附分子1和血管细胞黏附分子1
Arch Ophthalmol. 2010 Oct;128(10):1281-6. doi: 10.1001/archophthalmol.2010.227.
3
Role of inflammation in previously untreated macular edema with branch retinal vein occlusion.炎症在未经治疗的分支视网膜静脉阻塞伴黄斑水肿中的作用。
BMC Ophthalmol. 2014 May 18;14:67. doi: 10.1186/1471-2415-14-67.
4
Aqueous humor analyses of diabetic macular edema patients with subretinal fluid.对伴有视网膜下液的糖尿病性黄斑水肿患者的房水分析。
Sci Rep. 2021 Oct 25;11(1):20985. doi: 10.1038/s41598-021-00442-z.
5
Aqueous Humor Levels of Soluble Vascular Endothelial Growth Factor Receptor and Inflammatory Factors in Diabetic Macular Edema.糖尿病性黄斑水肿中可溶性血管内皮生长因子受体及炎性因子的房水水平
Ophthalmologica. 2017;238(1-2):81-88. doi: 10.1159/000475603. Epub 2017 Jun 1.
6
Aqueous Humor Cytokine Levels and Anatomic Response to Intravitreal Ranibizumab in Diabetic Macular Edema.糖尿病性黄斑水肿患者玻璃体内注射雷珠单抗后房水细胞因子水平及解剖学反应
JAMA Ophthalmol. 2018 Apr 1;136(4):382-388. doi: 10.1001/jamaophthalmol.2018.0179.
7
Aqueous Cytokine Expression and Higher Order OCT Biomarkers: Assessment of the Anatomic-Biologic Bridge in the IMAGINE DME Study.眼内液细胞因子表达和高阶 OCT 生物标志物：在 IMAGINE DME 研究中评估解剖-生物标志物联系。
Am J Ophthalmol. 2021 Feb;222:328-339. doi: 10.1016/j.ajo.2020.08.047. Epub 2020 Sep 5.
8
Study of aqueous cytokines in patients with different patterns of diabetic macular edema based on optical coherence tomography.基于光学相干断层扫描的不同类型糖尿病性黄斑水肿患者房水细胞因子研究
Int Ophthalmol. 2018 Feb;38(1):241-249. doi: 10.1007/s10792-017-0453-2. Epub 2017 Feb 3.
9
Role of inflammation in diabetic macular edema.炎症在糖尿病性黄斑水肿中的作用。
Ophthalmologica. 2014;232(3):127-35. doi: 10.1159/000364955. Epub 2014 Oct 18.
10
Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema.血管内皮生长因子和细胞间黏附分子1的玻璃体水平与糖尿病性黄斑水肿相关。
Ophthalmology. 2005 May;112(5):806-16. doi: 10.1016/j.ophtha.2004.11.045.

引用本文的文献

1
Molecular-Genetic Biomarkers of Diabetic Macular Edema.糖尿病性黄斑水肿的分子遗传生物标志物
J Clin Med. 2024 Dec 5;13(23):7426. doi: 10.3390/jcm13237426.
2
Inflammatory mediators in diabetic retinopathy: Deriving clinicopathological correlations for potential targeted therapy.糖尿病性视网膜病变中的炎症介质：为潜在靶向治疗推导出临床病理相关性。
Indian J Ophthalmol. 2021 Nov;69(11):3035-3049. doi: 10.4103/ijo.IJO_1326_21.
3
Hyperreflective foci as biomarkers for inflammation in diabetic macular edema: Retrospective analysis of treatment naïve eyes from south India.

本文引用的文献

1
High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy.高迁移率族蛋白盒1与增殖性糖尿病视网膜病变患者玻璃体内的炎症生物标志物
Mol Vis. 2011;17:1829-38. Epub 2011 Jul 6.
2
Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans.在人类中，单次玻璃体内注射 1.5mg 与 3.0mg 贝伐单抗后的眼内药代动力学。
Retina. 2011 Oct;31(9):1877-84. doi: 10.1097/IAE.0b013e318217373c.
3
Comparison of intravitreal bevacizumab and ranibizumab treatment for diabetic macular edema.
高反射病灶作为糖尿病性黄斑水肿炎症的生物标志物：来自印度南部未经治疗的眼睛的回顾性分析。
Indian J Ophthalmol. 2021 May;69(5):1197-1202. doi: 10.4103/ijo.IJO_2627_20.
4
Statement of the German Ophthalmological Society, the German Retina Society, and the Professional Association of Ophthalmologists in Germany on treatment of diabetic macular edema : Dated August 2019.德国眼科学会、德国视网膜学会和德国眼科医生专业协会关于糖尿病性黄斑水肿治疗的声明：日期为2019年8月。
Ophthalmologe. 2021 Jan;118(Suppl 1):40-67. doi: 10.1007/s00347-020-01244-w.
5
[Statement of the German Ophthalmological Society, the Retinological Society and the Professional Association of Ophthalmologists in Germany on treatment of diabetic macular edema : Situation August 2019].[德国眼科学会、视网膜病学会及德国眼科医生专业协会关于糖尿病性黄斑水肿治疗的声明：2019年8月情况]
Ophthalmologe. 2020 Mar;117(3):218-247. doi: 10.1007/s00347-019-01015-2.
6
The role of inflammation in diabetic eye disease.炎症在糖尿病眼病中的作用。
Semin Immunopathol. 2019 Jul;41(4):427-445. doi: 10.1007/s00281-019-00750-7. Epub 2019 Jun 7.
7
Aqueous Humor Cytokine Levels and Anatomic Response to Intravitreal Ranibizumab in Diabetic Macular Edema.糖尿病性黄斑水肿患者玻璃体内注射雷珠单抗后房水细胞因子水平及解剖学反应
JAMA Ophthalmol. 2018 Apr 1;136(4):382-388. doi: 10.1001/jamaophthalmol.2018.0179.
8
Systemic Associations with Residual Subretinal Fluid after Ranibizumab in Diabetic Macular Edema.糖尿病性黄斑水肿患者接受雷珠单抗治疗后视网膜下液残留的全身相关性
J Ophthalmol. 2017;2017:4834201. doi: 10.1155/2017/4834201. Epub 2017 Jul 27.
9
Novel Therapies in Development for Diabetic Macular Edema.糖尿病性黄斑水肿的新型治疗方法研发
Curr Diab Rep. 2015 Oct;15(10):75. doi: 10.1007/s11892-015-0652-z.
比较玻璃体内注射贝伐单抗和雷珠单抗治疗糖尿病性黄斑水肿。
J Ocul Pharmacol Ther. 2011 Aug;27(4):373-7. doi: 10.1089/jop.2010.0195. Epub 2011 Jun 1.
4
ICAM-1: getting a grip on leukocyte adhesion.细胞间黏附分子-1：掌控白细胞黏附
J Immunol. 2011 May 1;186(9):5021-3. doi: 10.4049/jimmunol.1100646.
5
Update on nonsurgical therapy for diabetic macular edema.糖尿病性黄斑水肿的非手术治疗进展。
Curr Opin Ophthalmol. 2011 May;22(3):185-9. doi: 10.1097/ICU.0b013e3283459724.
6
Visual prognosis and vitreous molecules after vitrectomy for macular edema with branch retinal vein occlusion.视网膜分支静脉阻塞所致黄斑水肿玻璃体切割术后的视觉预后及玻璃体分子变化
Clin Ophthalmol. 2011;5:223-9. doi: 10.2147/OPTH.S16552. Epub 2011 Feb 15.
7
Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF.贝伐单抗治疗不仅能中和血管内皮生长因子（VEGF），还能使病理性眼内环境恢复正常。
Mol Vis. 2010 Oct 27;16:2175-84.
8
Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration.渗出性年龄相关性黄斑变性中的单核细胞趋化蛋白1、细胞间黏附分子1和血管细胞黏附分子1
Arch Ophthalmol. 2010 Oct;128(10):1281-6. doi: 10.1001/archophthalmol.2010.227.
9
A prospective, randomized comparison of intravitreal triamcinolone acetonide versus intravitreal bevacizumab (avastin) in diffuse diabetic macular edema.玻璃体内注射曲安奈德与玻璃体内注射贝伐单抗（阿瓦斯汀）治疗弥漫性糖尿病性黄斑水肿的前瞻性随机对照研究
Middle East Afr J Ophthalmol. 2010 Jul;17(3):250-3. doi: 10.4103/0974-9233.65496.
10
Intravitreal triamcinolone.玻璃体内曲安奈德。
Ophthalmologica. 2011;225(1):1-20. doi: 10.1159/000317909. Epub 2010 Aug 7.