Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.
作者信息
Gu Liangcai, Eisman Eli B, Dutta Somnath, Franzmann Titus M, Walter Stefan, Gerwick William H, Skiniotis Georgios, Sherman David H
机构信息
Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, 48109, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Mar 14;50(12):2795-8. doi: 10.1002/anie.201005280. Epub 2011 Feb 23.
Abstract
摘要
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Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.curacin生物合成途径中的串联酰基载体蛋白促进具有协同效应的连续多酶反应。
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Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.α-酮戊二酸引发卷曲霉素 A 生物合成中卤化酶的构象转换。
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14099-104. doi: 10.1073/pnas.1006738107. Epub 2010 Jul 26.
2
Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.在库拉菌素生物合成中，o-磺酸化作用先于聚酮脱羧链终止。
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3
Metamorphic enzyme assembly in polyketide diversification.聚酮化合物多样化过程中的变质酶组装
Nature. 2009 Jun 4;459(7247):731-5. doi: 10.1038/nature07870.
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The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis.串联酰基载体蛋白结构域在多不饱和脂肪酸生物合成中的作用。
J Am Chem Soc. 2008 May 21;130(20):6336-7. doi: 10.1021/ja801911t. Epub 2008 Apr 29.
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Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.来自巨大鞘丝藻的CurF的ECH2催化结构域的晶体结构。对参与聚酮链β-分支的脱羧酶的见解。
J Biol Chem. 2007 Dec 7;282(49):35954-63. doi: 10.1074/jbc.M703921200. Epub 2007 Oct 10.
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The chemical versatility of natural-product assembly lines.天然产物装配线的化学多样性。
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The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.枯草芽孢杆菌中PksX巨型复合体产物杆菌烯的鉴定。
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1506-9. doi: 10.1073/pnas.0610503104. Epub 2007 Jan 18.
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Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair.库拉索霉素A生物合成途径中脱水与脱羧反应的代谢偶联：一对具有不同作用机制的酶的功能鉴定
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