Łukasik-Głebocka Magdalena, Matuszkiewicz Eryk
Oddzial Toksykologii im. dr Wandy Błeńskiej z Ośrodkiem Informacji Toksykologicznej Szpital im. Franciszka Raszei ul. Mickiewicza 2, Poznań.
Przegl Lek. 2010;67(8):640-2.
"Poppers" is the street name for volatile nitrites offered by online shops and sex-shops for their aphrodisiac and euphoric properties. Although nitrites have been abused since the late 1960s, recently they became popular in Poland. Recreational poppers using was associated with homosexual men at first. Currently they are commonly reported among heterosexual men and regular dicso participants. Advertisements of these substances tempt potential buyers with the promise of a legal narcotic high. Easy access and the sense of safety make these products the reason of acute toxicity. Volatile nitrites relaxes smooth muscle, the consequent intense peripheral vasodilatation produces flushing, a fall in blood pressure, and reflex increase in heart rate. These effects are accompanied by feeling of warmth, euphoria and intensifying of sexual pleasure. Serious poisoning results in severe methaemoglobinaemia, coma, respiratory and cardiovascular failure, and even death. Skin and mucous contact with poppers can produce a crusty lesion at the site. This article presents the case of 44-years old male hospitalized three times in Toxicology Department after history of poppers abusing. Methaemoglobinaemia (26.4%) and tracheobronchial irritation were the main symptoms observed. Patient was given specific therapy with methylene blue.
“Poppers”是在线商店和性用品店出售的挥发性亚硝酸盐的俗称，因其具有催情和欣快作用。尽管自20世纪60年代末以来亚硝酸盐就被滥用，但最近在波兰开始流行。起初，娱乐性使用Poppers与男同性恋者有关。目前，在异性恋男性和普通迪斯科参与者中也普遍有报告。这些物质的广告以合法的麻醉性快感吸引潜在买家。容易获取和安全感使这些产品成为急性中毒的原因。挥发性亚硝酸盐可使平滑肌松弛，随之而来的强烈外周血管扩张会导致脸红、血压下降和心率反射性增加。这些效应还伴有温暖感、欣快感和性快感增强。严重中毒会导致严重的高铁血红蛋白血症、昏迷、呼吸和心血管衰竭，甚至死亡。皮肤和黏膜接触Poppers会在接触部位产生结痂性病变。本文介绍了一名44岁男性的病例，该患者在有Poppers滥用史后三次入住毒理学部。观察到的主要症状是高铁血红蛋白血症（26.4%）和气管支气管刺激。患者接受了亚甲蓝的特效治疗。
