肝细胞癌的危险因素：在贝尔格莱德（塞尔维亚）进行的一项病例对照研究。

Risk factors for hepatocellular carcinoma: a case-control study in Belgrade (Serbia).

作者信息

Kanazir Milena, Boricic Ivan, Delic Dragan, Tepavcevic Darija Kisic, Knezevic Aleksandra, Jovanovic Tanja, Pekmezovic Tatjana

机构信息

Institute of Public Health of Serbia, Belgrade, Serbia.

出版信息

Tumori. 2010 Nov-Dec;96(6):911-7.

PMID:21388051

Abstract

AIMS AND BACKGROUND

The objective of this case-control study was to test the existing hypotheses about factors related to the occurrence of hepatocellular carcinoma in the population of Belgrade (Serbia).

METHODS AND STUDY DESIGN

The investigation was conducted between 2004 and 2007 and consisted of 45 newly diagnosed, histologically confirmed hepatocellular carcinoma patients and 90 individually gender- and age-matched hospital controls. Conditional univariate and multivariate logistic regression analyses were applied.

RESULTS

A highly statistically significant association (P = 0.001) was demonstrated between hepatocellular carcinoma and HBsAg positivity and the presence of hepatitis C virus antibodies. Diabetes mellitus was significantly (P = 0.018) associated with an increased risk of hepatocellular carcinoma. A statistically significant inverse association was shown between low parity and the risk of hepatocellular carcinoma (P = 0.033). The risk increased significantly with a longer history of cigarette smoking (P = 0.044), as well as the daily consumption of hard liquor (P = 0.049). A weekly intake of fish (P = 0.003) and yogurt (P = 0.003) and daily intake of boiled vegetables (P = 0.001) were reported more frequently by controls than hepatocellular carcinoma cases. In the current study, a high intake of salty food also significantly increased the risk of hepatocellular carcinoma (P = 0.027). Based on multivariate analysis, the presence of hepatitis C virus antibodies (OR = 24.6, P = 0.001) and duration of smoking > or =25 years (OR = 3.8, P = 0.020) were significantly related to hepatocellular carcinoma, whereas the daily consumption of boiled vegetables (OR = 0.1, P = 0.011) was inversely associated with the risk of hepatocellular carcinoma.

CONCLUSIONS

The findings obtained in the current study support the hypotheses that non-viral factors, such as lifestyle factors, reproductive factors, and a history of diabetes, might be involved in the etiology of hepatocellular carcinoma.

摘要

目的与背景

本病例对照研究的目的是检验关于塞尔维亚贝尔格莱德人群中肝细胞癌发生相关因素的现有假说。

方法与研究设计

研究于2004年至2007年进行，包括45例新诊断的、经组织学确诊的肝细胞癌患者以及90例个体性别和年龄匹配的医院对照。应用条件单变量和多变量逻辑回归分析。

结果

肝细胞癌与乙肝表面抗原阳性及丙型肝炎病毒抗体的存在之间显示出高度统计学显著关联（P = 0.001）。糖尿病与肝细胞癌风险增加显著相关（P = 0.018）。低生育次数与肝细胞癌风险之间显示出统计学显著的负相关（P = 0.033）。吸烟史较长（P = 0.044）以及每日饮用烈性酒（P = 0.049）时，风险显著增加。对照者比肝细胞癌病例更频繁地报告每周食用鱼类（P = 0.003）和酸奶（P = 0.003）以及每日食用水煮蔬菜（P = 0.001）。在本研究中，高盐食物摄入量高也显著增加了肝细胞癌风险（P = 0.027）。基于多变量分析，丙型肝炎病毒抗体的存在（比值比 = 24.6，P = 0.001）以及吸烟持续时间≥25年（比值比 = 3.8，P = 0.020）与肝细胞癌显著相关，而每日食用水煮蔬菜（比值比 = 0.1，P = 0.011）与肝细胞癌风险呈负相关。