Widimsky J, Kuchel O, Debinski W, Thibault G
Laboratory of the Autonomic Nervous System, Clinical Research Institute of Montréal, Qué., Canada.
Can J Physiol Pharmacol. 1990 Mar;68(3):408-12. doi: 10.1139/y90-057.
The influence of prolonged high salt intake on intravascular volume, right atrial pressure, plasma atrial natriuretic factor, and extra-atrial tissue (lung, kidney, and liver) COOH- and NH2-terminal atrial natriuretic factor content was investigated in normotensive rats. Despite prolonged high salt (8% NaCl) intake for 5 weeks, total intravascular volume was not impaired. However, right atrial pressure was increased by 54% (p less than 0.01) after salt loading. Although this increment in right atrial pressure should favor atrial natriuretic factor release after NaCl intake, plasma atrial natriuretic factor (COOH-terminal) concentrations markedly decreased from 97.8 +/- 27 to 38.9 +/- 8 pg/mL. Sodium and circulatory homeostasis was, however, well preserved. The lungs contained the highest levels of COOH- and NH2-terminal atrial natriuretic factor. Salt loading resulted in increased concentrations of low as well as high molecular weight atrial natriuretic factor in the lung but not in the kidney or the liver. Our study indicates a limited role of atrial natriuretic factor in adaptation to prolonged salt consumption in rats. Dissociation between right atrial pressure and plasma atrial natriuretic factor after salt intake implicates other factors regulating circulating peptide levels. Prolonged salt intake increases lung generation of atrial natriuretic factor.
在正常血压大鼠中，研究了长期高盐摄入对血管内容量、右心房压力、血浆心钠素以及心房外组织（肺、肾和肝）COOH末端和NH2末端心钠素含量的影响。尽管持续5周摄入高盐（8%氯化钠），但总血管内容量并未受损。然而，盐负荷后右心房压力增加了54%（p<0.01）。虽然盐摄入后右心房压力的这种增加应有利于心钠素的释放，但血浆心钠素（COOH末端）浓度却从97.8±27显著降至38.9±8 pg/mL。然而，钠和循环稳态仍保持良好。肺中COOH末端和NH2末端心钠素的含量最高。盐负荷导致肺中低分子量和高分子量心钠素的浓度增加，但肾和肝中未增加。我们的研究表明心钠素在大鼠适应长期盐消耗中的作用有限。盐摄入后右心房压力与血浆心钠素之间的分离意味着存在其他调节循环肽水平的因素。长期盐摄入会增加肺中心钠素的生成。
