Department of Neurology, University of Ulm, Ulm, Germany.
Neurodegener Dis. 2011;8(5):283-8. doi: 10.1159/000324372. Epub 2011 Mar 10.
Camptocormia (CC) is defined as a trunkal flexion which worsens while standing, sitting and walking and disappears in the supine position. CC is a well-known clinical phenomenon in patients with generalized neuromuscular disorders like polymyositis, myasthenia gravis or motor neuron diseases, and it is also described in the context of movement disorders like Parkinson's disease (PD) or multiple system atrophy. In association with PD, CC seems to be a rare symptom which occurs preferentially in late stages of the disease. Currently, there are 3 main hypotheses on the pathogenesis of CC in PD, i.e. a focal myopathy of the trunk muscles, axial dystonia and a drug-induced etiology. This review gives a synopsis and critical acclaim of these 3 etiologies and refers to the current study data and possible treatment strategies.
屈肌型脊柱前凸（CC）的定义为站立、坐立和行走时躯干弯曲加重，而仰卧时消失。CC 是一种在多发性肌炎、重症肌无力或运动神经元病等全身性神经肌肉疾病患者中常见的临床现象，也可见于帕金森病（PD）或多系统萎缩等运动障碍疾病中。在与 PD 相关的情况下，CC 似乎是一种罕见的症状，主要发生在疾病的晚期。目前，关于 PD 中 CC 的发病机制有 3 种主要假说，即躯干肌肉局灶性肌病、轴性肌张力障碍和药物引起的病因。本文综述了这 3 种病因，并对其进行了评价，同时还参考了目前的研究数据和可能的治疗策略。
