Department of Neurosciences, Movement Disorder Program, Medical University of South Carolina, 326 Calhoun Street, Suite 308/MSC 108, Charleston, SC 29425, USA.
Curr Neurol Neurosci Rep. 2012 Aug;12(4):386-91. doi: 10.1007/s11910-012-0280-9.
Postural deformities in parkinsonian syndromes are well recognized, but poorly understood and largely refractory to available therapies. In recent times a number of hypotheses have been proposed to explain the underlying etiology of anterocollis and camptocormia, but currently there is no consensus. As these conditions are more precisely characterized we begin to uncover that this is a heterogeneous and evolving phenomenon. These conditions bring to light the inadequacies of our current tools to study biomechanics of posture, neuromuscular disorders, and dystonic muscular contractions. The development of objective, accurate tools to directly study and measure the severity of these postural disorders will allow for further understanding of the pathophysiology, the development of novel therapeutics, and adequate clinical trial design.
帕金森综合征中的姿势畸形是众所周知的，但了解甚少，且对现有治疗方法大多具有抗性。近来，许多假说被提出以解释前屈颈和脊柱前凸的潜在病因，但目前尚无共识。随着这些病症被更精确地描述，我们开始发现这是一种异质且不断演变的现象。这些病症凸显了我们当前研究姿势生物力学、神经肌肉紊乱和张力障碍性肌肉收缩的工具的不足。开发客观、准确的工具来直接研究和测量这些姿势障碍的严重程度，将有助于进一步了解病理生理学，开发新的治疗方法，并进行充分的临床试验设计。
