Wren Leia, Kent Stephen J
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia.
Hum Vaccin. 2011 Apr;7(4):466-73. doi: 10.4161/hv.7.4.14123. Epub 2011 Apr 1.
The partial efficacy of the recent HIV-1 vaccine trial in Thailand has rejuvenated the HIV vaccine field. There are now clear opportunities to dissect the potential correlates of protection against HIV-1. Comparisons of three major HIV-1 vaccine strategies used in human efficacy trials to date highlight a possible role for antibody-dependent cellular cytotoxicty (ADCC), rather than cytotoxic T lymphocyte or neutralizing antibody responses, in protective immunity. This review explores the HIV vaccine efficacy trials performed to date and the potential role for ADCC antibodies in assisting protective immunity.
近期在泰国开展的HIV-1疫苗试验所取得的部分成效，为HIV疫苗领域注入了新的活力。目前，剖析针对HIV-1的潜在保护相关因素存在明确的机会。对迄今为止在人体疗效试验中使用的三种主要HIV-1疫苗策略进行比较后发现，在保护性免疫中，抗体依赖性细胞毒性作用（ADCC）而非细胞毒性T淋巴细胞或中和抗体反应可能发挥了作用。本综述探讨了迄今为止开展的HIV疫苗疗效试验以及ADCC抗体在协助保护性免疫方面的潜在作用。
