Department of Emergency Medicine, Waikato Hospital, Hamilton, New Zealand.
Eur J Emerg Med. 2011 Oct;18(5):279-81. doi: 10.1097/MEJ.0b013e3283456807.
Antibiotic administration at the time of wound manipulation has not been shown to decrease infection rates for simple traumatic wounds. Antibiotic administration at the time of initial emergency department (ED) presentation, however, has not been explored. Patients presenting to the ED with simple traumatic wounds received 1 g of oral flucloxacillin, or identical placebo, at triage. Wound closure was completed at the discretion of a physician blinded to study contents. Wound infection rates were determined at 1 month. Time from drug administration to wound manipulation was 64.3 min [95% confidence interval (CI) 36.6-91.9] placebo versus 75.0 min (95% CI: 51.7-98.3) flucloxacillin, P=0.657. Six of 36 patients (17%) reported wound infection in the placebo group, and four of 34 (12%) in the flucloxacillin group, P=0.736. Administration of oral flucloxacillin at triage failed to reduce the rate of wound infection for simple traumatic wounds closed in the ED.
在处理创伤性简单伤口时给予抗生素并未显示能降低感染率。然而，在最初的急诊就诊时给予抗生素尚未得到探索。在分诊时，将 1 克口服氟氯西林或相同的安慰剂给予就诊于急诊的简单创伤性伤口患者。伤口闭合由一位对研究内容不知情的医生决定。在 1 个月时确定伤口感染率。从给药到伤口处理的时间为 64.3 分钟（95%置信区间：36.6-91.9），安慰剂组为 75.0 分钟（95%置信区间：51.7-98.3），氟氯西林组，P=0.657。安慰剂组有 6 名患者（17%）报告伤口感染，氟氯西林组有 4 名患者（12%），P=0.736。在分诊时给予口服氟氯西林未能降低在急诊室闭合的简单创伤性伤口的感染率。
