Mengin-Lecreulx D, van Heijenoort J
Unité Associée du CNRS, Biochimie Moléculaire et Cellulaire, Université Paris-Sud, Orsay, France.
FEMS Microbiol Lett. 1990 Jan 1;54(1-3):129-33. doi: 10.1016/0378-1097(90)90270-z.
It was speculated that the increase of the UDP-GlcNAc pool observed with chloramphenicol can modulate the residual PEP:UDP-GlcNAc-enolpyruvate activity of fosfomycin-treated cells. This provided an explanation on how chloramphenicol can insure the formation of enough UDP-MurNAc-pentapeptide to sustain peptidoglycan synthesis at a rate that will antagonize fosfomycin-induced lysis.