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[肉毒素A治疗痉挛性斜颈患者前后的疼痛综合征]

[Pain syndrome in patients with spastic torticollis before and after the treatment with dysport].

作者信息

Zalialova Z A, Abdulgalimova D M

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(11 Pt 2):62-5.

Abstract

53 patients with the syndrome of spastic torticollis (ST) were examined to assess the nature and dynamics of pain syndrome during the treatment with dysport. The patient's condition assessment was examined before and 1 month after injection of dysport using Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). The TWSTRS scale includes 3 subscales (severity of torticollis, disability and pain), each of which consists of the attributes estimated for scores. Observations showed that 1 month after injection of dysport with doses ranging from 500 to 1000 units in the affected muscles of the neck pain intensity decreased by an average of 55%, which has averaged 6,2 points of the TWSTRS pain subscale (p<0,01). Observation confirmed that pain is one of the leading complaints in patients with ST. Pathogenetic basis of the pain formation in this disease and prospects of botulinum toxin therapy in pain syndrome correction were discussed.

摘要

对53例痉挛性斜颈(ST)综合征患者进行检查,以评估在使用Dysport治疗期间疼痛综合征的性质和动态变化。在注射Dysport前及注射后1个月,使用多伦多西部痉挛性斜颈评定量表(TWSTRS)对患者的病情进行评估。TWSTRS量表包括3个分量表(斜颈严重程度、功能障碍和疼痛),每个分量表由按分数评估的属性组成。观察结果显示,在颈部受影响肌肉注射500至1000单位剂量的Dysport后1个月,疼痛强度平均降低了55%,TWSTRS疼痛分量表平均降低了6.2分(p<0.01)。观察证实疼痛是ST患者的主要主诉之一。讨论了该疾病疼痛形成的发病机制基础以及肉毒杆菌毒素疗法在纠正疼痛综合征方面的前景。

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