Department of Molecular Biology, University of Bergen, Bergen.
J Toxicol Environ Health A. 2011;74(7-9):494-507. doi: 10.1080/15287394.2011.550559.
Atlantic cod (Gadus morhua) is an essential species in North Atlantic fisheries and increasingly relevant as an aquaculture species. However, potential conflicts with both coastal industry and petroleum industry expanding into northern waters make it important to understand how effluents (produced water, pharmaceuticals, food contaminants, and feed contaminants) affect the growth, reproduction, and health of this species in order to maintain a sustainable cod population and a healthy human food source, and to discover biomarkers for environmental monitoring and risk assessment. The ongoing genome sequencing effort of Atlantic cod has opened the possibility for a systems biology approach to elucidate molecular mechanisms of toxicity. Our study aims to be a first step toward such a systems toxicology understanding of genomic responses to environmental insults. A toxicogenomic approach was initiated that is combining data generated from proteomics analyses and transcriptomics analyses, and the concurrent development of searchable expressed sequence tags (EST) databases and genomic databases. This interdisciplinary study may also open new possibilities of gene annotation and pathway analyses.
北大西洋鳕鱼（Gadus morhua）是北大西洋渔业的重要物种，作为一种水产养殖物种的相关性也日益增加。然而，随着沿海工业和石油工业向北部水域扩张，潜在的冲突使得了解废水（生产用水、药品、食品污染物和饲料污染物）如何影响该物种的生长、繁殖和健康变得非常重要，以便维持可持续的鳕鱼种群和健康的人类食物来源，并发现用于环境监测和风险评估的生物标志物。正在进行的北大西洋鳕鱼基因组测序工作为系统生物学方法阐明毒性的分子机制开辟了可能性。我们的研究旨在朝着对环境胁迫的基因组反应进行系统毒理学理解迈出的第一步。已经启动了一种毒理基因组学方法，该方法结合了从蛋白质组学分析和转录组学分析中产生的数据，以及可搜索的表达序列标签（EST）数据库和基因组数据库的同时开发。这项跨学科研究还可能为基因注释和途径分析开辟新的可能性。
