Department of Pharmacology, M.G.V's Pharmacy College, Panchavati, Nasik, Maharashtra 422003, India.
Nat Prod Res. 2011 Sep;25(16):1549-59. doi: 10.1080/14786410903335190. Epub 2011 Jul 11.
Chronic administration of myricetin (100 and 300 mg kg⁻¹, p.o., for 4 weeks) isolated from Vitis vinifera (Vitaceae) ameliorated hypertension and oxidative stress induced by deoxycorticosterone acetate (DOCA)-salt in rats. Myricetin treatment reduced systolic blood pressure, vascular reactivity changes and reversed the DOCA-induced increase in heart rate. Urinary sodium excretion was significantly decreased in animals treated with myricetin compared to the DOCA group when measured by flame photometer. The cumulative concentration response curve of serotonin (5-HT) and angiotensin II (Ang II) were shifted towards the right in rats treated with myricetin using the isolated rat fundus strip and ascending colon, respectively. Increased levels of thiobarbituric acid reactive substances and decreased levels of superoxide dismutase, catalase and reduced glutathione in the heart tissue were observed in animals treated with DOCA, which were reversed by myricetin. Thus, myricetin shows antihypertensive and antioxidant properties in the DOCA model of hypertension.
从葡萄属（葡萄科）中分离得到的杨梅素经口给予（100 和 300mg/kg，共 4 周）可改善去氧皮质酮醋酸盐（DOCA）-盐诱导的大鼠高血压和氧化应激。杨梅素治疗可降低收缩压、血管反应性变化，并逆转 DOCA 诱导的心率增加。与 DOCA 组相比，用火焰光度计测量时，杨梅素治疗的动物尿钠排泄明显减少。用分离的大鼠胃底条和升结肠分别处理杨梅素后，5-羟色胺（5-HT）和血管紧张素 II（Ang II）的累积浓度反应曲线向右移位。在 DOCA 处理的动物心脏组织中观察到硫代巴比妥酸反应性物质水平升高，超氧化物歧化酶、过氧化氢酶和还原型谷胱甘肽水平降低，杨梅素可逆转这种情况。因此，杨梅素在高血压的 DOCA 模型中具有降压和抗氧化作用。
