Othman Nur Syakirah, Che Roos Nur Aishah, Aminuddin Amilia, Murthy Jaya Kumar, A Hamid Adila, Ugusman Azizah
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia.
Front Pharmacol. 2022 Aug 25;13:976247. doi: 10.3389/fphar.2022.976247. eCollection 2022.
Hypertension and diabetes mellitus are among the most prevalent diseases affecting people from all walks of life. Medicinal herbs have garnered interest as potential agents for the prevention and treatment of diabetes mellitus and hypertension due to their multiple beneficial effects. Roxb. (PS) is an edible medicinal plant that has been traditionally used in Asia for treating hypertension and diabetes mellitus. This review is aimed to provide comprehensive information from the literature on the effects of PS on hypertension and diabetes mellitus. A computerized database search was performed on Scopus, PubMed and Web of Science databases with the following set of keywords: Piper sarmentosum AND diabetes mellitus OR diabetic OR diabetes OR hyperglycemia OR blood glucose OR HbA1c OR glycated hemoglobin OR hemoglobin A1c OR hyperten OR blood pressure. A total of 47 articles were screened and 14 articles published between the years 1998 until 2021 were included for data extraction, comprising of six articles on antihypertensive and eight articles on antidiabetic effects of PS. These studies consist of two studies and eleven animal studies. Meta-analysis of three studies on hypertension showed that PS versus no treatment significantly lowered the systolic blood pressure with mean difference (MD) -39.84 mmHg (95% confidence interval (CI) -45.05, -34.62; p < 0.01), diastolic blood pressure with MD -26.68 mmHg (95% CI -31.48, -21.88; p < 0.01), and mean arterial pressure with MD -30.56 mmHg (95% CI -34.49, -26.63; p < 0.01). Most of the studies revealed positive effects of PS against hypertension and diabetes mellitus, suggesting the potential of PS as a natural source of antidiabetic and antihypertensive agents.
高血压和糖尿病是影响各行各业人群的最常见疾病。草药因其多种有益作用而作为预防和治疗糖尿病及高血压的潜在药物受到关注。罗勒（PS）是一种可食用的药用植物，在亚洲传统上用于治疗高血压和糖尿病。本综述旨在提供文献中关于罗勒对高血压和糖尿病影响的全面信息。在Scopus、PubMed和Web of Science数据库上进行了计算机化数据库搜索，使用了以下关键词组：罗勒 与 糖尿病 或 糖尿病患者 或 糖尿病 或 高血糖血症 或 血糖 或 HbA1c 或 糖化血红蛋白 或 血红蛋白A1c 或 高血压 或 血压。共筛选了47篇文章，纳入了1998年至2021年间发表的14篇文章进行数据提取，其中包括6篇关于罗勒降压作用的文章和8篇关于罗勒抗糖尿病作用的文章。这些研究包括两项人体研究和十一项动物研究。对三项关于高血压的研究进行的荟萃分析表明，与未治疗相比，罗勒显著降低收缩压，平均差值（MD）为-39.84 mmHg（95%置信区间（CI）为-45.05，-34.62；p < 0.01），舒张压MD为-26.68 mmHg（95% CI为-31.48，-21.88；p < 0.01），平均动脉压MD为-30.56 mmHg（95% CI为-34.49，-26.63；p < 0.01）。大多数研究揭示了罗勒对高血压和糖尿病的积极作用，表明罗勒作为抗糖尿病和抗高血压药物天然来源的潜力。
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