韩国首尔与急性肠胃炎相关的病毒病原体

Viral agents associated with acute gastroenteritis in Seoul, Korea.

作者信息

Park S H, Kim E J, Oh S A, Kim C K, Choi S S, Cho S J, Han K Y, Lee J I, Kim M Y, Jung H S, Chun D S, Kim H S

机构信息

Seoul Metropolitan Government Research Institute of Public Health and Environment, Virus team, Republic of Korea.

出版信息

Clin Lab. 2011;57(1-2):59-65.

PMID:21391466

Abstract

BACKGROUND

The present study was carried out to describe the epidemiologic characteristics of viral gastroenteritis and determine the phylogenetic composition of norovirus strains detected in hospitalized children with acute gastroenteritis in Seoul, Korea.

METHODS AND RESULTS

In total, 10,603 stool samples were collected from 2004 to 2008 and tested by RT-PCR or ELISA. In 4,170 (39.3%) samples at least one viral pathogen was present. Rotavirus (RoV) (1,864, 17.5%) was found to be the causative agent followed by norovirus (NoV) (1,845, 17.4%), human adenovirus (HAdV) (266, 2.5%), human astrovirus (HAstV) (194, 1.8%), and sapovirus (SV) (1, 0.009%). Five GI genotypes (GI-1, GI-3, GI-4, GI-8, and GI-9) and eight GII genotypes (GII-2, GII-3, GII-4, GII-6, GII-7, GII-12, GII-16, and GII-17) of NoV were identified in acute gastroenteritis patients in 2008.

CONCLUSIONS

The genetic characteristics of norovirus and the epidemiologic patterns of a viral pathogen from acute gastroenteritis patients may give potentially effective data for epidemiological studies in Seoul, Korea.

摘要

背景

本研究旨在描述病毒性肠胃炎的流行病学特征，并确定在韩国首尔患有急性肠胃炎的住院儿童中检测到的诺如病毒株的系统发育组成。

方法与结果

2004年至2008年共收集了10603份粪便样本，并通过逆转录聚合酶链反应（RT-PCR）或酶联免疫吸附测定（ELISA）进行检测。在4170份（39.3%）样本中至少存在一种病毒病原体。发现轮状病毒（RoV）（1864份，17.5%）是病原体，其次是诺如病毒（NoV）（1845份，17.4%）、人腺病毒（HAdV）（266份，2.5%））、人星状病毒（HAstV）（194份，1.8%）和札幌病毒（SV）（1份，0.009%）。2008年在急性肠胃炎患者中鉴定出了诺如病毒的5种GI基因型（GI-1、GI-3、GI-4、GI-8和GI-9）和8种GII基因型（GII-2、GII-3、GII-4、GII-6、GII-7、GII-12、GII-16和GII-17）。