使用钾烷基和烷氧基甲基三氟硼酸盐直接对杂芳基进行烷基化。
Direct alkylation of heteroaryls using potassium alkyl- and alkoxymethyltrifluoroborates.
机构信息
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
出版信息
Org Lett. 2011 Apr 1;13(7):1852-5. doi: 10.1021/ol2003572. Epub 2011 Mar 10.
Abstract
A direct alkylation of various heteroaryls using stoichiometric potassium alkyl- and alkoxymethyltrifluoroborates has been developed. This method leads to the synthesis of complex substituted heterocycles, which have been obtained with yields up to 89%.
摘要
本文开发了一种使用化学计量的钾烷基和烷氧基甲基三氟硼酸盐对各种杂芳基进行直接烷基化的方法。该方法可用于合成复杂取代的杂环化合物，产率高达 89%。
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