遗传性尿崩症大鼠（布拉特洛伯大鼠）脑核中的心房利钠肽

Atrial natriuretic peptides in brain nuclei of rats with inherited diabetes insipidus (Brattleboro rats).

作者信息

Bahner U, Geiger H, Palkovits M, Ganten D, Michel J, Heidland A

机构信息

Department of Nephrology, Medical Clinic of the University, Würzburg, FRG.

出版信息

Neuroendocrinology. 1990 Jun;51(6):721-7. doi: 10.1159/000125417.

DOI:10.1159/000125417

PMID:2141922

Abstract

The concentration of atrial natriuretic peptides (ANF) was measured radioimmunologically in 18 selected microdissected brain areas of rats with inherited diabetes insipidus (Brattleboro rats) and their control rats (Long-Evans rats). In 7 brain areas known to be involved in the regulation of fluid homeostasis or blood pressure (subfornical organ, organum vasculosum lamina terminalis, periventricular preoptic nucleus, perifornical nucleus, nucleus of the solitary tract, tegmentum pontis, arcuate nucleus) ANF concentration was significantly changed. After restoration of antidiuresis with the V2 receptor agonist 1-desamino-8-D-arginine vasopressin (DDAVP) ANF levels of Brattleboro rats adapted at least partly to those of the control rats in all brain areas except the subfornical organ. Furthermore, ANF was then significantly changed in the supraoptic and paraventricular nuclei of DDAVP-treated diabetes insipidus rats. These data show that the central ANF system is sensitive for changes in electrolyte and fluid homeostasis.

摘要

采用放射免疫法测定了遗传性尿崩症大鼠（布拉特洛维大鼠）及其对照大鼠（朗-埃文斯大鼠）18个选定的显微解剖脑区中心房钠尿肽（ANF）的浓度。在已知参与体液平衡或血压调节的7个脑区（穹窿下器、终板血管器、室周视前核、穹窿周核、孤束核、脑桥被盖、弓状核）中，ANF浓度发生了显著变化。用V2受体激动剂1-去氨基-8-D-精氨酸加压素（DDAVP）恢复抗利尿作用后，除穹窿下器外，布拉特洛维大鼠所有脑区的ANF水平至少部分适应了对照大鼠的水平。此外，在经DDAVP治疗的尿崩症大鼠的视上核和室旁核中，ANF随后发生了显著变化。这些数据表明，中枢ANF系统对电解质和体液平衡的变化敏感。