Department of Nuclear Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea.
Neoplasma. 2011;58(3):245-50. doi: 10.4149/neo_2011_03_245.
The aim of the current study was to investigate the prognostic value of SUV(max) in patients with completely resected early stage (stage I and II) NSCLC. A retrospective review identified 76 patients with surgically resected early (stage I and II) NSCLC who received F-18 FDG PET/CT at diagnosis of cancer. Survival analysis was conducted using Kaplan-Meier analysis, and survival curves stratified by age, sex, mediastinal lymph node involvement, SUV(max), and TNM staging were generated for estimation of overall survival and disease free survival (DFS). Independent predictive factors for survival were determined using Cox proportional hazard model. For overall survival, the median survival of the patients with tumor SUV(max)≤ 6.7 was 48.9 months and was significantly longer than the patients with tumor SUV(max)>6.7 (Log rank test, Χ²=18.01, p5.9. The median survival of the patients with tumor SUV(max)≤ 5.9 was 31.7 months (Log rank test, Χ²=16, p=0.0001). In conclusion, high FDG uptake measured by F-18 FDG PET/CT might have a prognostic value for overall survival and DFS in surgically resected early stage (stage I and II) NSCLC even after stratified by pathologic stages.
本研究旨在探讨完全切除的早期（Ⅰ期和Ⅱ期）非小细胞肺癌（NSCLC）患者中 SUV(max)的预后价值。回顾性分析了 76 例在诊断癌症时接受 F-18 FDG PET/CT 检查的手术切除的早期（Ⅰ期和Ⅱ期）NSCLC 患者。采用 Kaplan-Meier 分析进行生存分析，并根据年龄、性别、纵隔淋巴结受累、SUV(max)和 TNM 分期生成生存曲线，以估计总生存率和无病生存率（DFS）。使用 Cox 比例风险模型确定生存的独立预测因素。对于总生存率，肿瘤 SUV(max)≤6.7 的患者的中位生存期为 48.9 个月，明显长于肿瘤 SUV(max)>6.7 的患者（对数秩检验，Χ²=18.01，p<0.001）。肿瘤 SUV(max)≤5.9 的患者的中位生存期为 31.7 个月（对数秩检验，Χ²=16，p=0.0001）。总之，即使按病理分期分层，F-18 FDG PET/CT 测量的高 FDG 摄取对手术切除的早期（Ⅰ期和Ⅱ期）NSCLC 的总生存率和 DFS 可能具有预后价值。
