Department of Pediatrics, University of British Columbia BC Children's Hospital, Vancouver, BC, Canada.
Diabet Med. 2011 Apr;28(4):424-7. doi: 10.1111/j.1464-5491.2011.03238.x.
Our aim was to validate three diabetes case definitions for children and adolescents aged <20 years in Canada using administrative and clinical data in the province of British Columbia.
We identified potential cases of diabetes from physician claims, hospitalizations and prescription drug records between 1992/1993 and 2007/2008 using the three different case definitions, which included a national standard as well as two regionally developed case definitions. Each case definition used a different combination of administrative data; however, only one definition used prescription drug records. The sensitivity of each definition was calculated against the 'gold standard' of diagnosed cases recorded in British Columbia's Children's Hospital Endocrinology and Diabetes Unit clinical database.
During this time period, 2611 patients were seen at the British Columbia's Children's Hospital. The sensitivities (95% CIs) of the national and two regional case definitions were 0.95 (0.941-0.958), 0.97 (0.964-0.977) and 0.82 (0.800-0.830), respectively.
Our results highlight the benefit of regional case definitions that exploit the availability of different data sources, but also support that a nationally derived definition is sensitive among children and adolescents.
本研究旨在使用不列颠哥伦比亚省的行政和临床数据，验证加拿大三种适用于<20 岁儿童和青少年的糖尿病病例定义。
我们使用三种不同的病例定义，包括一个国家标准和两个区域性开发的病例定义，从医生的索赔、住院和处方药记录中确定潜在的糖尿病病例。这些病例定义在 1992/1993 年至 2007/2008 年期间使用不同的行政数据组合；然而，只有一个定义使用了处方药记录。每个病例定义的敏感性均针对不列颠哥伦比亚省儿童医院内分泌和糖尿病科临床数据库中记录的诊断病例的“金标准”进行计算。
在此期间，不列颠哥伦比亚省儿童医院共诊治了 2611 名患者。国家标准和两个区域性病例定义的敏感性（95%CI）分别为 0.95（0.941-0.958）、0.97（0.964-0.977）和 0.82（0.800-0.830）。
我们的研究结果突出了利用不同数据源的区域性病例定义的优势，但也支持全国范围内制定的定义在儿童和青少年中具有敏感性。
