Skin Institute and School of Dermatology, Greater Kailash, New Delhi, India.
Clin Exp Dermatol. 2011 Jul;36(5):495-8. doi: 10.1111/j.1365-2230.2011.04025.x. Epub 2011 Mar 11.
Granuloma annulare (GA) is a noninfectious necrobiotic granuloma, which can present as localized or generalized patterns. We present a case of generalized GA with multiple large open comedones over the lesions in a woman with hypothyroidism and diabetes mellitus. GA is associated with collagen and elastic-fibre damage, which may lead to loss of follicular support and resultant open comedone formation, analogous to solar elastosis or senile comedones. The rapid recovery of our patient after treatment with of oral hypoglycaemics supports the role of insulin resistance as a predisposing factor for GA.
环状肉芽肿（GA）是一种非传染性的坏死性肉芽肿，可表现为局限性或全身性。我们报告了一例患有甲状腺功能减退症和糖尿病的女性，其病变处出现多发性大开放性粉刺的全身性 GA。GA 与胶原和弹性纤维损伤有关，这可能导致毛囊支持丧失，从而形成开放性粉刺，类似于日光性弹性纤维病或老年性粉刺。我们的患者在口服降糖药治疗后迅速康复，这支持了胰岛素抵抗是 GA 的一个易感因素。
