University of Maryland, Department of Epidemiology and Public Health, 685 W Baltimore St, MSTF 336, Baltimore, MD 21201, USA.
Emerg Infect Dis. 2011 Mar;17(3):441-8. doi: 10.3201/eid1703.100502.
Trends in Staphylococcus aureus infections are not well described. To calculate incidence in overall S. aureus infection and invasive and noninvasive infections according to methicillin susceptibility and location, we conducted a 10-year population-based retrospective cohort study (1999-2008) using patient-level data in the Veterans Affairs Maryland Health Care System. We found 3,674 S. aureus infections: 2,816 (77%) were noninvasive; 2,256 (61%) were methicillin-resistant S. aureus (MRSA); 2,517 (69%) were community onset, and 1,157 (31%) were hospital onset. Sixty-one percent of noninvasive infections were skin and soft tissue infections; 1,112 (65%) of these were MRSA. Ten-year averaged incidence per 100,000 veterans was 749 (± 132 SD, range 549-954) overall, 178 (± 41 SD, range 114-259) invasive, and 571 (± 152 SD, range 364-801) noninvasive S. aureus infections. Incidence of all S. aureus infections significantly increased (p<0.001), driven by noninvasive, MRSA, and community-onset infections (p<0.001); incidence of invasive S. aureus infection significantly decreased (p<0.001).
金黄色葡萄球菌感染的趋势描述得并不完善。为了根据耐甲氧西林金黄色葡萄球菌（MRSA）的药敏性和感染部位来计算金黄色葡萄球菌总体感染、侵袭性和非侵袭性感染的发病率，我们利用退伍军人事务部马里兰医疗保健系统的患者水平数据进行了一项为期 10 年的基于人群的回顾性队列研究（1999-2008 年）。我们发现了 3674 例金黄色葡萄球菌感染：2816 例（77%）为非侵袭性感染；2256 例（61%）为 MRSA；2517 例（69%）为社区发病，1157 例（31%）为医院发病。61%的非侵袭性感染为皮肤和软组织感染；1112 例（65%）为 MRSA。每 10 万退伍军人中 10 年的平均发病率为 749（±132 SD，范围 549-954）总体感染、178（±41 SD，范围 114-259）侵袭性感染和 571（±152 SD，范围 364-801）非侵袭性金黄色葡萄球菌感染。所有金黄色葡萄球菌感染的发病率均显著增加（p<0.001），主要由非侵袭性、MRSA 和社区发病感染所致（p<0.001）；侵袭性金黄色葡萄球菌感染的发病率显著下降（p<0.001）。
