Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Kowloon, Hong Kong.
Euro Surveill. 2011 Mar 3;16(9):19807.
Phylogenetic analysis of the haemagglutinin (HA) gene shows that the influenza A(H1N1)2009 viruses collected in Hong Kong clustered in two main branches characterised by the E391E and E391K amino acids. The main branch E391K evolved in two sub-branches with N142D and S202T mutations that first appeared in March and July 2010, respectively, with the latter becoming the predominant strain. These genetic variants that emerged display similar antigenic characteristics.Concurrent with genetic surveillance, laboratories should continue monitoring the circulating viruses antigenically.
系统进化分析表明，在香港分离的甲型 H1N1 2009 流感病毒血凝素（HA）基因分为两大分支，其 E391 氨基酸分别为 E 或 K。分支 E391K 又分为两个亚分支，其中 N142D 和 S202T 突变最早分别于 2010 年 3 月和 7 月出现，后者逐渐成为主要流行株。这些新出现的基因变异具有相似的抗原性特征。除了进行基因监测，实验室还应继续监测具有流行特征的病毒抗原性。
