Lisanti M P, Rodriguez-Boulan E
Cornell University Medical College, Department of Cell Biology and Anatomy, New York, NY 10021.
Trends Biochem Sci. 1990 Mar;15(3):113-8. doi: 10.1016/0968-0004(90)90195-h.
The sorting signals that guide proteins to apical and basolateral surfaces of epithelial cells have remained elusive. Current evidence suggests a hierarchy of sorting information with multiple sorting signals (apical and basolateral) present in different domains of a given plasma membrane protein. The observation that covalently attached glycosyl-phosphatidylinositol (GPI) acts as a 'dominant' apical targeting signal is compatible with the involvement of glycolipids in epithelial protein sorting.
引导蛋白质到达上皮细胞顶端和基底外侧表面的分选信号一直难以捉摸。目前的证据表明，分选信息存在层级结构，在给定质膜蛋白的不同结构域中存在多种分选信号（顶端和基底外侧）。共价连接的糖基磷脂酰肌醇（GPI）作为“主导”的顶端靶向信号这一观察结果，与糖脂参与上皮蛋白分选的观点相符。
