Epilepsy and Clinical Neurophysiology, Children's Hospital Boston, Boston, MA 02115, USA.
Epileptic Disord. 2011 Mar;13(1):18-21. doi: 10.1684/epd.2011.0406.
The syndrome of malignant migrating partial seizures of infancy (MMPEI) is characterized by early onset of multiple seizures types, highly pharmaco-resistant seizures, and overall poor prognosis. In this study, we investigated retrospectively the efficacy of rufinamide (RUF) in five infants with MMPEI, by examining seizure type and frequency, EEG features and antiepileptic drug use. The data demonstrate that two of the five patients showed good efficacy and tolerability for RUF with a > 50% reduction in seizure frequency. The use of RUF for the treatment of MMPEI may therefore provide some hope for such infants and should be further validated. [Published with video sequences].
婴儿恶性游走性部分性癫痫发作综合征（MMPEI）的特征是多种癫痫发作类型的早期发作、高度药物抵抗性癫痫发作以及总体预后不良。在这项研究中，我们通过检查癫痫发作类型和频率、脑电图特征和抗癫痫药物使用情况，回顾性地研究了瑞马唑仑（RUF）在五例 MMPEI 婴儿中的疗效。数据表明，五例患者中有两例对 RUF 具有良好的疗效和耐受性，癫痫发作频率降低了 > 50%。因此，RUF 治疗 MMPEI 可能为这些婴儿提供了一些希望，应进一步验证。[发表时附有视频序列]。
