Queensland Children's Respiratory Centre and Children's Medical Research Institute, Royal Children's Hospital, Brisbane, QLD, Australia; Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Department of Respiratory Medicine, John Hunter Hospital, University of Newcastle, NSW, Australia.
Chest. 2011 Aug;140(2):324-330. doi: 10.1378/chest.10-2507. Epub 2011 Mar 10.
Despite the commonality of cough and its burden, there are no published data on the relationship between atopy or sex on objectively measured cough frequency or subjective cough scores in children. In 202 children with and without cough, we determined the effect of sex and atopy on validated cough outcome measurements (cough receptor sensitivity [CRS], objective cough counts, and cough scores). We hypothesized that in contrast to adult data, sex does not influence cough outcome measures, and atopy is not a determinant of these cough measurements.
We combined data from four previous studies. Atopy (skin prick test), the concentration of capsaicin causing two and five or more coughs (C2 and C5, respectively), objectively measured cough frequency, and cough scores were determined and their relationship explored. The children's (93 girls, 109 boys) mean age was 10.6 years (SD 2.9), and 56% had atopy.
In multivariate analysis, CRS was influenced by age (C2 coefficient, 5.9; P = .034; C5 coefficient, 29.1; P = .0001). Atopy and sex did not significantly influence any of the cough outcomes (cough counts, C2, C5, cough score) in control subjects and children with cough.
Atopy does not influence important cough outcome measures in children with and without chronic cough. However, age, but not sex, influences CRS in children. Unlike adult data, sex does not affect objective counts or cough score in children with and without chronic cough. Studies on cough in children should be age matched, but matching for atopic status and sex is less important.
尽管咳嗽很常见，且其负担很重，但目前尚无关于特应性或性别对儿童客观测量的咳嗽频率或主观咳嗽评分的关系的发表数据。在 202 例有咳嗽和无咳嗽的儿童中，我们确定了性别和特应性对经过验证的咳嗽结局测量（咳嗽感受器敏感性[CRS]、客观咳嗽计数和咳嗽评分）的影响。我们假设与成人数据相反，性别不会影响咳嗽结局测量，特应性不是这些咳嗽测量的决定因素。
我们合并了四项先前研究的数据。确定了特应性（皮肤点刺试验）、引起两次和五次或更多咳嗽的辣椒素浓度（分别为 C2 和 C5）、客观测量的咳嗽频率和咳嗽评分，并探讨了它们之间的关系。儿童（93 名女孩，109 名男孩）的平均年龄为 10.6 岁（标准差 2.9），56%有特应性。
在多变量分析中，CRS 受年龄影响（C2 系数，5.9；P =.034；C5 系数，29.1；P =.0001）。在对照组和慢性咳嗽儿童中，特应性和性别均未显著影响任何咳嗽结局（咳嗽计数、C2、C5、咳嗽评分）。
特应性不会影响有和无慢性咳嗽儿童的重要咳嗽结局测量。然而，年龄而不是性别会影响儿童的 CRS。与成人数据不同，性别不会影响有和无慢性咳嗽儿童的客观计数或咳嗽评分。儿童咳嗽研究应进行年龄匹配，但对特应性状态和性别的匹配不太重要。
