Coruzzi P, Ravanetti C, Alberici M, Novarini A
Università degli Studi di Parma, Istituto di Semeiotica Medica.
Clin Ter. 1990 Jan 15;132(1):45-9.
The controlled study was carried out on 15 patients with essential hypertension not sufficiently controlled after one month of monotherapy with an ACE-inhibitor. To the above therapy was therefore associated a low dosage diuretic (indapamide 2.5 mg/day). The observation period was of 12 weeks. The delapril-indapamide combination was found to be very effective in reducing blood pressure values; no significant metabolic adverse effects were observed.
对15例原发性高血压患者进行了对照研究,这些患者在接受一个月的ACE抑制剂单一疗法后血压控制不佳。因此,在上述治疗基础上加用小剂量利尿剂(吲达帕胺2.5毫克/天)。观察期为12周。发现地拉普利-吲达帕胺联合用药在降低血压值方面非常有效;未观察到明显的代谢不良反应。