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[抗高血压治疗:新型血管紧张素转换酶抑制剂地拉普利与吲达帕胺的联合应用]

[Antihypertensive treatment: a combination of delapril, a new ACE-inhibitor, and indapamide].

作者信息

Coruzzi P, Ravanetti C, Alberici M, Novarini A

机构信息

Università degli Studi di Parma, Istituto di Semeiotica Medica.

出版信息

Clin Ter. 1990 Jan 15;132(1):45-9.

PMID:2139371
Abstract

The controlled study was carried out on 15 patients with essential hypertension not sufficiently controlled after one month of monotherapy with an ACE-inhibitor. To the above therapy was therefore associated a low dosage diuretic (indapamide 2.5 mg/day). The observation period was of 12 weeks. The delapril-indapamide combination was found to be very effective in reducing blood pressure values; no significant metabolic adverse effects were observed.

摘要

对15例原发性高血压患者进行了对照研究,这些患者在接受一个月的ACE抑制剂单一疗法后血压控制不佳。因此,在上述治疗基础上加用小剂量利尿剂(吲达帕胺2.5毫克/天)。观察期为12周。发现地拉普利-吲达帕胺联合用药在降低血压值方面非常有效;未观察到明显的代谢不良反应。

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