Division of Gastrointestinal Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
J Clin Pathol. 2012 Jul;65(7):666-8. doi: 10.1136/jclinpath-2011-200639. Epub 2012 Mar 29.
Tubular carcinoid is a rare variant of appendiceal well-differentiated neuroendocrine tumour. Although considered benign lesions, the small infiltrating tubules that characterise the tumour may raise concern for metastatic adenocarcinoma. To our knowledge, the cytokeratin 7 (CK7)/cytokeratin 20 (CK20) expression profile of these neoplasms remains unexplored.
The authors characterised the CK7/CK20 immunophenotype and Ki-67 expression of the eight available tubular carcinoids seen at their institution from 1991 to 2011.
CK7 and CK20 staining was variable, ranging from none to focal staining for either or both CK7 and CK20, to diffuse expression of CK7 or CK20.
The CK7/CK20 expression profile is of limited value when the differential diagnosis includes primary tubular carcinoid and well-differentiated metastatic adenocarcinoma. In such cases, careful attention to the location of the neoplasm, mitotic count and presence or absence of an associated classic carcinoid component are more useful for arriving at the correct diagnosis.
管状类癌是阑尾分化良好的神经内分泌肿瘤的罕见变异型。尽管被认为是良性病变，但肿瘤特征性的小浸润性管状结构可能会引起对转移性腺癌的担忧。据我们所知，这些肿瘤的细胞角蛋白 7（CK7）/细胞角蛋白 20（CK20）表达谱尚未被探索。
作者分析了他们机构在 1991 年至 2011 年间发现的 8 例管状类癌的 CK7/CK20 免疫表型和 Ki-67 表达。
CK7 和 CK20 的染色结果各不相同，从 CK7 和 CK20 均无或局灶性染色，到 CK7 或 CK20 弥漫性表达。
当鉴别诊断包括原发性管状类癌和分化良好的转移性腺癌时，CK7/CK20 的表达谱价值有限。在这种情况下，仔细关注肿瘤的位置、有丝分裂计数以及是否存在经典类癌成分更有助于做出正确的诊断。
