Oda Eiji, Kawai Ryu
Medical Check-up Center, Tachikawa Medical Center, Nagachou 2-2-16, Nagaoka, Niigata, 940-0053, Japan.
Heart Vessels. 2012 Jan;27(1):29-36. doi: 10.1007/s00380-011-0123-7. Epub 2011 Mar 11.
Bilirubin is a potent antioxidant, and serum total bilirubin (TB) is reported to be negatively associated with cardiovascular disease (CVD). There has been no report on the association between TB and CVD prevalence in Japanese. The aim of the study is to examine the association between TB and CVD prevalence in a Japanese health screening population. Prevalence of CVD was studied in 3,375 Japanese men and 2,069 Japanese women. Odds ratios (ORs) of each higher quintile of TB using the lowest quintile as the reference in men and of each higher tertile of TB using the lowest tertile as the reference in women were calculated for coronary heart disease (CHD) and stroke adjusting for age, liver function tests, smoking, physical activity, and alcohol consumption. The ORs [95% confidence intervals (CIs)] for CHD and stroke of the 2nd, 3rd, 4th, and 5th quintiles of TB were 0.63 (0.37-1.07) and 0.49 (0.24-1.00), 0.45 (0.22-0.90) and 0.65 (0.28-1.51), 0.69 (0.39-1.20) and 0.37 (0.15-0.87), and 0.61 (0.34-1.09) and 0.40 (0.18-0.92), respectively in men. The ORs (95% CIs) for CHD and stroke of the 2nd and 3rd tertiles of TB were 1.32 (0.49-3.54) and 0.35 (0.13-0.93), and 1.26 (0.44-3.62) and 0.34 (0.13-0.93), [corrected] respectively in women. Low TB was associated with the higher prevalence of CHD and stroke in men and with the higher prevalence of stroke in women among a Japanese health screening population.
胆红素是一种强效抗氧化剂，据报道血清总胆红素（TB）与心血管疾病（CVD）呈负相关。关于日本人群中TB与CVD患病率之间的关联尚无报告。本研究的目的是调查日本健康筛查人群中TB与CVD患病率之间的关联。对3375名日本男性和2069名日本女性的CVD患病率进行了研究。在男性中，以最低五分位数为参照，计算TB每升高一个五分位数时冠心病（CHD）和中风的比值比（OR）；在女性中，以最低三分位数为参照，计算TB每升高一个三分位数时CHD和中风的OR，并对年龄、肝功能检查、吸烟、体力活动和饮酒情况进行校正。男性中，TB第二、三、四、五分位数时CHD和中风的OR[95%置信区间（CI）]分别为0.63（0.37 - 1.07）和0.49（0.24 - 1.00）、0.45（0.22 - 0.90）和0.65（0.28 - 1.51）、0.69（0.39 - 1.20）和0.37（0.15 - 0.87）、0.61（0.34 - 1.09）和0.40（0.18 - 0.92）。女性中，TB第二和三分位数时CHD和中风的OR（95%CI）分别为1.32（0.49 - 3.54）和0.35（0.13 - 0.93）、1.26（0.44 - 3.62）和0.34（0.13 - 0.93）[校正后]。在日本健康筛查人群中，低TB与男性CHD和中风的较高患病率以及女性中风的较高患病率相关。
