Metabolomics/Proteomics, Biological Profiling, Applied Quantitative Genotherapeutics, Pfizer Inc., 620 Memorial Drive, Cambridge, MA 02139, USA.
Curr Drug Metab. 2011 May;12(4):345-58. doi: 10.2174/138920011795202947.
Metabolomics is emerging as a promising systems biology approach for many research fields including functional genomics, disease diagnosis, nutrition science, and drug discovery. Following rapid development in academic and research institutes, metabolomics is drawing an attention in the pharmaceutical industry. This review aims to highlight the practical value of metabolomics in (a) potentially validating more novel therapeutic targets and indications, (b) facilitating decision-making on the advancement of therapeutics in the drug development process, and (c) leading to better patient stratification and cost-effective clinical trials, through the application of LC/MS/MRM-based targeted metabolomics studies at a relatively low cost in pharmaceutical companies. This paper provides a brief history of the development of metabolomics and common strategies for conducting metabolomics studies. The pros and cons of the most important technologies and the major components of metabolomics studies are reviewed and discussed. Finally, selected metabolomics study examples are reviewed to illustrate how metabolomics can be used to simultaneously capture underlying biochemical changes associated with pharmaceutical interventions, and effectively produce more accurate and/or alternative efficacy and ADR biomarkers, thereby, greatly extending our knowledge of disease, protein function and drug action and maximally benefiting the pharmaceutical industry.
代谢组学作为一种有前途的系统生物学方法，正在多个研究领域崭露头角，包括功能基因组学、疾病诊断、营养科学和药物发现。在学术和研究机构的快速发展之后，代谢组学在制药行业引起了关注。本综述旨在强调代谢组学在以下方面的实际价值：(a) 潜在验证更多新颖的治疗靶点和适应症；(b) 在药物开发过程中促进治疗药物的决策；(c) 通过在制药公司中以相对较低的成本应用基于 LC/MS/MRM 的靶向代谢组学研究，实现更好的患者分层和具有成本效益的临床试验。本文简要介绍了代谢组学的发展历史和进行代谢组学研究的常见策略。综述并讨论了最重要技术的优缺点以及代谢组学研究的主要组成部分。最后，回顾了选定的代谢组学研究实例，以说明代谢组学如何用于同时捕获与药物干预相关的潜在生化变化，并有效地产生更准确和/或替代的疗效和 ADR 生物标志物，从而极大地扩展我们对疾病、蛋白质功能和药物作用的认识，并使制药行业受益匪浅。
