Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
Eur J Neurosci. 2011 Mar;33(6):1037-44. doi: 10.1111/j.1460-9568.2011.07601.x.
As our understanding of adult neurogenesis increases, hopes rise that neurological disorders and neuronal losses might be addressed one day by neural stem cell-based regenerative therapies. However, evaluating the efficacy and safety of any neurogenesis-based intervention requires a means to monitor neurogenesis in vivo and, so far, no such imaging techniques are available for human studies. Nevertheless, using imaging techniques presently available to clinicians, i.e. magnetic resonance imaging, positron emission tomography and optical imaging, significant progress has been made in this direction over the last decade. This review describes the current state-of-the-art for each imaging technique, and shows that detection of neurogenesis could theoretically be achieved using current imaging devices. Indeed, in vivo imaging of neurogenesis has already been achieved in mice using transgenic model systems. However, the imaging of human neurogenesis still requires the development of methods to reliably target the neural stem cells and the neuronal precursors in vivo.
随着我们对成人神经发生的理解不断加深，人们希望有一天能够通过基于神经干细胞的再生疗法来治疗神经紊乱和神经元缺失。然而，评估任何基于神经发生的干预措施的疗效和安全性都需要一种方法来监测体内神经发生，到目前为止，还没有适用于人类研究的这种成像技术。尽管如此，利用目前临床医生可用的成像技术，即磁共振成像、正电子发射断层扫描和光学成像，在过去十年中，在这方面已经取得了重大进展。本文综述了每种成像技术的最新现状，并表明使用当前的成像设备理论上可以检测神经发生。事实上，已经使用转基因模型系统在小鼠中实现了神经发生的体内成像。然而，人类神经发生的成像仍然需要开发可靠地在体内靶向神经干细胞和神经前体细胞的方法。
