硝苯地平、孕酮及卧床休息在抑制先兆早产宫缩中的成功率比较
Comparison of success rate of nifedipine, progesterone, and bed rest for inhibiting uterine contraction in threatened preterm labor.
作者信息
Chawanpaiboon Saifon, Pimol Kanjana, Sirisomboon Ratre
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
J Obstet Gynaecol Res. 2011 Jul;37(7):787-91. doi: 10.1111/j.1447-0756.2010.01434.x. Epub 2011 Mar 13.
AIM
To compare the success rates and gestational ages at delivery of nifedipine, proluton depot administration as a tocolytic agent and bed rest groups to pregnant women with threatened preterm labor.
MATERIAL AND METHODS
A total of 150 pregnant women with threatened preterm labor between 28 and 35 weeks of gestation were enrolled in the study. All women underwent contraction inhibition randomly sorted into three groups. The first and second groups were inhibited with nifedipine and proluton depot, respectively. The third group was admitted for bed rest.
RESULTS
Nifedipine, proluton depot and bed rest can be used to inhibit contraction in threatened preterm labor. However, when time-to-event test was used, nifedipine took the shortest time for contraction inhibition with statistical significance.
CONCLUSION
Nifedipine, proluton depot and bed rest can be used successfully to inhibit contraction in threatened preterm labor. However, nifedipine took the shortest time to inhibit uterine contraction in threatened preterm labor.
目的
比较硝苯地平、长效黄体酮作为宫缩抑制剂给药以及卧床休息组对先兆早产孕妇的成功率和分娩孕周。
材料与方法
本研究共纳入150例妊娠28至35周的先兆早产孕妇。所有孕妇均接受宫缩抑制治疗，并随机分为三组。第一组和第二组分别用硝苯地平和长效黄体酮进行抑制。第三组入院卧床休息。
结果
硝苯地平、长效黄体酮和卧床休息均可用于抑制先兆早产的宫缩。然而，当采用事件发生时间检验时，硝苯地平抑制宫缩所需时间最短，具有统计学意义。
结论
硝苯地平、长效黄体酮和卧床休息均可成功用于抑制先兆早产的宫缩。然而，硝苯地平在抑制先兆早产宫缩方面所需时间最短。
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