Laboratory of Microbiology, Ospedale Alessandro Manzoni, Via dell'Eremo, 9/11, 23900, Lecco, Italy.
Diagn Microbiol Infect Dis. 2011 Apr;69(4):363-9. doi: 10.1016/j.diagmicrobio.2010.10.016.
Beginning on April 2007, a prospective multicenter study was performed to investigate prevalence and epidemiology of microbial pathogens causing bloodstream infections (BSIs). Twenty microbiology laboratories participated to the survey over a 1-year period. A total of 11,638 episodes of BSI occurred in 11 202 patients, with 8.5% (n=985) of episodes being polymicrobial. Of 12 781 causative organisms, aerobic Gram-negative bacteria were 47.4% (n=6058), whereas Gram-positives accounted for 43.9% (n=5608). The remaining organisms included fungal species (n=924, 7.2%) and anaerobes (n=191, 1.5%). The most prevalent agents were Escherichia coli (21.7%), Staphylococcus aureus (14.9%), Staphylococcus epidermidis (8.2%), Pseudomonas aeruginosa (7.0%), and Enterococcus faecalis (6.3%). Isolates recovered from patients admitted to medical, surgical, and intensive care units accounted for 62.9%, 17.7%, and 19.4% of cases, respectively. BSIs were classified as hospital-acquired in 67.2% of cases. Compared with previous studies, our data show an increasing role of Gram-negative bacteria among both hospital- and community-acquired blood isolates.
自 2007 年 4 月起，一项前瞻性多中心研究旨在调查引起血流感染（BSI）的微生物病原体的流行情况和流行病学。二十个微生物学实验室参与了为期一年的调查。在 11202 名患者中，共发生了 11638 例 BSI，其中 8.5%（n=985）为混合感染。在 12781 株病原体中，需氧革兰氏阴性菌占 47.4%（n=6058），而革兰氏阳性菌占 43.9%（n=5608）。其余的病原体包括真菌（n=924，7.2%）和厌氧菌（n=191，1.5%）。最常见的病原体包括大肠杆菌（21.7%）、金黄色葡萄球菌（14.9%）、表皮葡萄球菌（8.2%）、铜绿假单胞菌（7.0%）和粪肠球菌（6.3%）。从入住内科、外科和重症监护病房的患者中分离出的菌株分别占 62.9%、17.7%和 19.4%。67.2%的 BSI 被归类为医院获得性感染。与之前的研究相比，我们的数据显示，无论是医院获得性还是社区获得性血液分离株，革兰氏阴性菌的作用都在增加。
