Dermatology Unit, Kaplan Medical Center, 76100 Rechovot, Israel.
Clin Dermatol. 2011 Mar-Apr;29(2):237-40. doi: 10.1016/j.clindermatol.2010.09.015.
The term "isotopic response" was coined by Wolf et al in 1995 to describe the occurrence of a new skin disorder at the site of another unrelated and already healed skin disease. When this term was found to be unsuitable for Medline searches because it generated hundreds of references that were linked with radioactive isotopes, it was changed to "Wolf's isotopic response" and eventually included as such in Stedman's Illustrated Dictionary of Dermatology Eponyms. Our search of the literature yielded 176 cases of Wolf's isotopic response. We describe this entity and present representative clinical examples. Some problems in the definition of Wolf's isotopic response are provided with special emphasis on its overlapping with the Koebner isomorphic response, a similar, but different, phenomenon. Also addressed are a number of issues associated with another term, "isotopic nonresponse," which had been introduced in analogy to the "isomorphic nonresponse" for describing the absence of an eruption at the site of another unrelated and already healed skin disease, or the sparing of the sites of another unrelated and already healed skin disease. In the spirit of the present issue, this contribution discusses only the clinical morphology and not the etiology, pathomechanism, or molecular biology of Wolf's isotopic response.
“同位反应”一词由 Wolf 等人于 1995 年提出，用于描述在另一种已治愈的非相关皮肤病部位出现新的皮肤疾病。当发现这个术语不适合在 Medline 搜索中使用，因为它会产生数百个与放射性同位素相关的参考文献时，它被更改为“Wolf 的同位反应”，最终被收录在 Stedman 的《皮肤病学术语词典》中。我们对文献进行了搜索，共发现 176 例 Wolf 的同位反应。我们描述了这种情况，并提供了代表性的临床病例。特别强调了其与 Koebner 同形反应的重叠问题，这是一种类似但不同的现象。还讨论了与另一个术语“同位无反应”相关的一些问题，该术语是类比“同形同构无反应”而引入的，用于描述在另一种非相关且已治愈的皮肤病部位没有出现皮疹，或者在另一种非相关且已治愈的皮肤病部位没有受到影响。本着本期的精神，本贡献仅讨论了临床形态，而未讨论 Wolf 的同位反应的病因、发病机制或分子生物学。
