Böhmer D, Seegräber M, Horváth O N, Wollenberg A
Klinik und Poliklinik für Dermatologie und Allergologie, LMU, Frauenlobstr. 9, 80337, München, Deutschland.
Städtisches Klinikum Thalkirchner Straße, München, Deutschland.
Hautarzt. 2020 Jan;71(1):53-56. doi: 10.1007/s00105-019-4445-1.
Wolf's isotopic response describes the eruption of a secondary, pathogenically independent skin disease within the borders of a primary, already healed skin disease. The exact mechanism is unknown, but the restriction to diseases with a known T‑cell component in the pathogenesis suggests an involvement of persistent local immune activation. We report the case of an 87-year-old woman who developed bullous pemphigoid lesions within the boundaries of a previous, already healed herpes zoster C7-C8, which had been diagnosed clinically and treated 2 months previously. Histopathological examination revealed subepidermal blisters, and indirect immunofluorescence showed IgG antibodies against the basal membrane zone. Both BP 180 and BP 230 enzyme-linked immunoassays (ELISAs) were positive. Based on these findings, we diagnosed a bullous pemphigoid arising on the site of the already healed herpes zoster, linked by an isotopic response.
沃尔夫同形反应描述了在一种原发性、已愈合的皮肤病边界内出现的继发性、病因独立的皮肤病的发作。确切机制尚不清楚，但在发病机制中对具有已知T细胞成分的疾病的限制表明持续的局部免疫激活参与其中。我们报告了一例87岁女性的病例，她在先前已愈合的C7 - C8带状疱疹边界内出现了大疱性类天疱疮皮损，该带状疱疹在2个月前已临床诊断并接受治疗。组织病理学检查显示表皮下水疱，间接免疫荧光显示针对基底膜带的IgG抗体。BP 180和BP 230酶联免疫吸附测定（ELISA）均为阳性。基于这些发现，我们诊断为在已愈合的带状疱疹部位出现的大疱性类天疱疮，由同形反应引起。
