鉴定和优化四氢-2H-3-苯并氮杂环庚烷-2-酮类作为鲨烯合酶抑制剂。
Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors.
机构信息
Bayer Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Building 460, D-42096 Wuppertal, Germany.
出版信息
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2554-8. doi: 10.1016/j.bmcl.2011.02.004. Epub 2011 Feb 17.
PMID:21396815
Abstract
Novel squalene synthase inhibitors are disclosed. SAR and pharmacological profile of selected compounds are discussed.
摘要
新型鲨烯合酶抑制剂被披露。选定化合物的 SAR 和药理学特性进行了讨论。
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